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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/104522
Birth weight and adult IQ, but not anxious-depressive psychopathology, are associated with cortical surface area: a study in twins.
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Background Previous research suggests that low birth weight (BW) induces reduced brain cortical sur- face area (SA) which would persist until at least early adulthood. Moreover, low BW has been linked to psychiatric disorders such as depression and psychological distress, and to altered neurocognitive profiles. Aims We present novel findings obtained by analysing high-resolution structural MRI scans of 48 twins; specifically, we aimed: i) to test the BW-SA association in a middle-aged adult sam- ple; and ii) to assess whether either depression/anxiety disorders or intellectual quotient (IQ) influence the BW-SA link, using a monozygotic (MZ) twin design to separate environ- mental and genetic effects. Results Both lower BW and decreased IQ were associated with smaller total and regional cortical SA in adulthood. Within a twin pair, lower BW was related to smaller total cortical and regional SA. In contrast, MZ twin differences in SA were not related to differences in either IQ or depression/anxiety disorders.
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CÓRDOVA PALOMERA, Aldo, et al. Birth weight and adult IQ, but not anxious-depressive psychopathology, are associated with cortical surface area: a study in twins. PLoS One. 2015. Vol. 10, num. 6, pags. e:0129616. ISSN 1932-6203. [consulted: 24 of June of 2026]. Available at: https://hdl.handle.net/2445/104522