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Detection of heteromers formed by cannabinoid CB1, dopamine D2, and adenosine A2A G-protein-coupled receptors by combining bimolecular fluorescence complementation and bioluminescence energy transfer

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dc.contributor.authorNavarro Brugal, Gemma
dc.contributor.authorCarriba Domínguez, Paulina
dc.contributor.authorGandía, Jorge
dc.contributor.authorCiruela Alférez, Francisco
dc.contributor.authorCasadó, Vicent
dc.contributor.authorCortés Tejedor, Antonio
dc.contributor.authorMallol Montero, Josefa
dc.contributor.authorCanela Campos, Enric I. (Enric Isidre), 1949-
dc.contributor.authorLluís i Biset, Carme
dc.contributor.authorFranco Fernández, Rafael
dc.date.accessioned2018-05-17T15:13:56Z
dc.date.available2018-05-17T15:13:56Z
dc.date.issued2008-10-11
dc.date.updated2018-05-17T15:13:56Z
dc.description.abstractFunctional interactions in signaling occur between dopamine D2 (D2R) and cannabinoid CB1 (CB1R) receptors, between CB1R and adenosine A2A (A2AR) receptors, and between D2R and A2AR. Furthermore, direct molecular interactions have been reported for the pairs CB1R-D2R, A2AR-D2R, and CB1R-A2AR. Here a combination of bimolecular fluorescence complementation and bioluminescence energy transfer techniques was used to identify the occurrence of D2R-CB1R-A2AR hetero-oligomers in living cells.
dc.format.extent11 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec564241
dc.identifier.issn1537-744X
dc.identifier.pmid18956124
dc.identifier.urihttps://hdl.handle.net/2445/122431
dc.language.isoeng
dc.publisherHindawi
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1100/tsw.2008.136
dc.relation.ispartofScientific World Journal, 2008, vol. 8, p. 1088-1097
dc.relation.urihttps://doi.org/10.1100/tsw.2008.136
dc.rightscc-by (c) Navarro Brugal, Gemma et al., 2008
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es
dc.sourceArticles publicats en revistes (Bioquímica i Biomedicina Molecular)
dc.subject.classificationAdenosina
dc.subject.classificationProteïnes
dc.subject.classificationReceptors cel·lulars
dc.subject.otherAdenosine
dc.subject.otherProteins
dc.subject.otherCell receptors
dc.titleDetection of heteromers formed by cannabinoid CB1, dopamine D2, and adenosine A2A G-protein-coupled receptors by combining bimolecular fluorescence complementation and bioluminescence energy transfer
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
Articles publicats en revistes (Bioquímica i Fisiologia)
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Articles publicats en revistes (Patologia i Terapèutica Experimental)