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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/215002
Relationship between chronic inflammation and Alzheimer's disease
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[eng] Alzheimer's disease is the most common form of dementia, accounting for 60 to 70% of total cases. It is a multifactorial neurodegenerative disease with devastating consequences for which there is still no cure. Considering the involvement of a chronic inflammatory state in other chronic diseases such as obesity or diabetes, the question arises about a possible relationship between chronic inflammation and Alzheimer's disease.
This review attempts to evaluate, based on current evidence, the knowledge that explains the interaction between the different molecular pathways involved in inflammatory processes that contribute to this chronic inflammatory state. Understanding these interactions is crucial, as proper management of chronic inflammatory processes could open the possibility of developing targeted therapies for Alzheimer's disease.
The literature review was conducted through an exhaustive search of information in databases such as PubMed and Scopus, as well as online journals and books. The sources were meticulously selected to ensure the most relevant and recent studies were included, providing a comprehensive overview of the current state of research in this.
Although there is documented evidence of the contribution of chronic inflammation to Alzheimer's disease, further studies and clinical trials are still necessary to fully justify this relationship. Identifying the specific molecular pathways involved in the inflammatory processes would be key to developing promising therapeutic strategies. These future therapies could potentially slow the progression of the disease or even prevent its development, providing hope for millions of patients and their families affected by this condition.
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Treballs Finals del Doble Grau de Farmàcia i Nutrició Humana i Dietètica de la Facultat Farmàcia i Ciències de l’Alimentació,Facultat Farmàcia i Ciències de l’Alimentació. Universitat de Barcelona. Curs: 2023-2024. Tutor: Maria Izquierdo Pulido.
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CORNELLÀ FRANCH, Laura. Relationship between chronic inflammation and Alzheimer's disease. [consulta: 26 de novembre de 2025]. [Disponible a: https://hdl.handle.net/2445/215002]