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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/175741
Endothelial-specific deficiency of megalin in the brain protects mice against high-fat diet challenge
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Background: The increasing risk of obesity and diabetes among other metabolic disorders are the consequence of shifts in dietary patterns with high caloric-content food intake. We previously reported that megalin regulates energy homeostasis using blood-brain barrier (BBB) endothelial megalin-deficient (EMD) mice, since these animals developed obesity and metabolic syndrome upon normal chow diet administration. Obesity in mid-life appears to be related to greater dementia risk and represents an increasing global health issue. We demonstrated that EMD phenotype induced impaired learning ability and recognition memory, neurodegeneration, neuroinflammation, reduced neurogenesis, and mitochondrial deregulation associated with higher mitochondrial mass in cortical tissues
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BARTOLOME, Fernando, et al. Endothelial-specific deficiency of megalin in the brain protects mice against high-fat diet challenge. Journal of Neuroinflammation. 2020. Vol. 17, num. 1. ISSN 1742-2094. [consulted: 15 of June of 2026]. Available at: https://hdl.handle.net/2445/175741