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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/165679
The integrin-mediated adhesion complex: cooption of signaling systems at the dawn of Metazoa
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The integrin-mediated adhesion machinery is the primary cell-matrix adhesion mechanism in Metazoa. The integrin adhesion complex, which modulates important aspects of the cell physiology, is composed of integrins (α and β subunits) and several scaffolding and signaling proteins. Integrins appeared to be absent in all non-metazoan eukaryotes so far analyzed, including fungi, plants, and choanoflagellates, the sister-group to Metazoa. Thus, integrins and, therefore, the integrin-mediated adhesion and signaling mechanism was considered a metazoan innovation. Recently, a broad comparative genomic analysis including new genome data from several unicellular organisms closely related to fungi and metazoans shattered previous views. The integrin adhesion and signaling complex is not specific to Metazoa, but rather it is present in apusozoans and holozoan protists. Thus, this important signaling and adhesion system predated the origin of Fungi and Metazoa, and was subsequently lost in fungi and choanoflagellates. This finding suggests that cooption played a more important role in the origin of Meta-zoa than previously believed. Here, we hypothesize that the integrin adhesome was ancestrally involved in signaling.
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SEBÉ PEDRÓS, Arnau and RUIZ TRILLO, Iñaki. The integrin-mediated adhesion complex: cooption of signaling systems at the dawn of Metazoa. Communicative & Integrative Biology. 2010. Vol. 3, num. 5, pags. 475-477. ISSN 1942-0889. [consulted: 10 of June of 2026]. Available at: https://hdl.handle.net/2445/165679