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Document embargat fins el 2150-01-01

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2001-03-15

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/225931

Human gamma-delta T cells are activated by intermediates of the the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis

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Activation of Vγ9/Vδ2 T cells by small nonprotein Ags is frequently observed after infection with various viruses, bacteria, and eukaryotic parasites. We suggested earlier that compounds synthesized by the 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway of isopentenyl pyrophosphate synthesis are responsible for the Vγ9/Vδ2 T cell reactivity of many pathogens. Using genetically engineered Escherichia coli knockout strains, we now demonstrate that the ability of E. coli extracts to stimulate γδ T cell proliferation is abrogated when genes coding for essential enzymes of the MEP pathway, dxr or gcpE, are disrupted or deleted from the bacterial genome.

Matèries

Biologia molecular, Cèl·lules T

Matèries (anglès)

Molecular biology, T cells

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Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

Citació

EBERL, Matthias, et al. Human gamma-delta T cells are activated by intermediates of the the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis. The Journal of Immunology. 2001. Vol. 166, num. 6, pags. 3655-3658. ISSN 0022-1767. [consulted: 22 of May of 2026]. Available at: https://hdl.handle.net/2445/225931

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