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Human gamma-delta T cells are activated by intermediates of the the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis
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Activation of Vγ9/Vδ2 T cells by small nonprotein Ags is frequently observed after infection with various viruses, bacteria, and eukaryotic parasites. We suggested earlier that compounds synthesized by the 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway of isopentenyl pyrophosphate synthesis are responsible for the Vγ9/Vδ2 T cell reactivity of many pathogens. Using genetically engineered Escherichia coli knockout strains, we now demonstrate that the ability of E. coli extracts to stimulate γδ T cell proliferation is abrogated when genes coding for essential enzymes of the MEP pathway, dxr or gcpE, are disrupted or deleted from the bacterial genome.
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EBERL, Matthias, et al. Human gamma-delta T cells are activated by intermediates of the the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis. The Journal of Immunology. 2001. Vol. 166, num. 6, pags. 3655-3658. ISSN 0022-1767. [consulted: 6 of June of 2026]. Available at: https://hdl.handle.net/2445/225931