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2021-06-01

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cc-by (c) Checa, Marti et al., 2021
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/180350

Dielectric Imaging of Fixed HeLa Cells by In-Liquid Scanning Dielectric Force Volume Microscopy

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https://doi.org/10.3390/nano11061402

Abstract

Mapping the dielectric properties of cells with nanoscale spatial resolution can be an important tool in nanomedicine and nanotoxicity analysis, which can complement structural and mechanical nanoscale measurements. Recently we have shown that dielectric constant maps can be obtained on dried fixed cells in air environment by means of scanning dielectric force volume microscopy. Here, we demonstrate that such measurements can also be performed in the much morechallenging case of fixed cells in liquid environment. Performing the measurements in liquid media contributes to preserve better the structure of the fixed cells, while also enabling accessing the local dielectric properties under fully hydrated conditions. The results shown in this work pave the way to address the nanoscale dielectric imaging of living cells, for which still further developments are required, as discussed here.

Subject

Microscòpia de força atòmica, Cèl·lules epitelials

Subject (English)

Atomic force microscopy, Epithelial cells

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Articles publicats en revistes (Enginyeria Electrònica i Biomèdica)
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
Publicacions de projectes de recerca finançats per la UE

Citation

CHECA NUALART, Martí, et al. Dielectric Imaging of Fixed HeLa Cells by In-Liquid Scanning Dielectric Force Volume Microscopy. Nanomaterials. 2021. Vol. 11, num. 6. ISSN 2079-4991. [consulted: 19 of August of 2026]. Available at: https://hdl.handle.net/2445/180350

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