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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/223824
Opportunities in proximity modulation: Bridging academia and industry
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Abstract
In the past decade, exciting therapeutic strategies to harness the ubiquitin-proteasome system (UPS) for degradation of target proteins have emerged. Proximity-inducing modalities are at the center of these strategies and act by modulating protein-protein interactions. While we are still learning to harvest this approach, it holds tremendous promise for developing treatments for hitherto undruggable proteins. Here, we discuss how academic efforts and academic-industrial collaboration have advanced the development of therapeutic modalities based on the principle of roximity induction. We make a case for forming a global academia-industry alliance to enhance access to training and expertise while accelerating innovation and translation from ground-breaking ideas to proof of concept in the clinic.
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MAYOR-RUIZ, Cristina, et al. Opportunities in proximity modulation: Bridging academia and industry. Molecular Cell. 2025. Vol. 85, num. 16, pags. 3012-3022. ISSN 1097-2765. [consulted: 13 of June of 2026]. Available at: https://hdl.handle.net/2445/223824