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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/223824
Opportunities in proximity modulation: Bridging academia and industry
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In the past decade, exciting therapeutic strategies to harness the ubiquitin-proteasome system (UPS) for degradation of target proteins have emerged. Proximity-inducing modalities are at the center of these strategies and act by modulating protein-protein interactions. While we are still learning to harvest this approach, it holds tremendous promise for developing treatments for hitherto undruggable proteins. Here, we discuss how academic efforts and academic-industrial collaboration have advanced the development of therapeutic modalities based on the principle of roximity induction. We make a case for forming a global academia-industry alliance to enhance access to training and expertise while accelerating innovation and translation from ground-breaking ideas to proof of concept in the clinic.
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MAYOR-RUIZ, Cristina, WINTER, Georg e., KOCH, Kerstin, CIULLI, Alessio, THOMÄ, Nicolas h., DIKIC, Ivan. Opportunities in proximity modulation: Bridging academia and industry. _Molecular Cell_. 2025. Vol. 85, núm. 16, pàgs. 3012-3022. [consulta: 3 de gener de 2026]. ISSN: 1097-2765. [Disponible a: https://hdl.handle.net/2445/223824]