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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/105867
Metabolomics reveals impaired maturation of HDL particles in adolescents with hyperinsulinaemic androgen excess.
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Hyperinsulinaemic androgen excess (HIAE) in prepubertal and pubertal girls usually precedes a broader pathological phenotype in adulthood that is associated with anovulatory infertility, metabolic syndrome and type 2 diabetes. The metabolic derangements that determine these long-term health risks remain to be clarified. Here we use NMR and MS-based metabolomics to show that serum levels of methionine sulfoxide in HIAE girls are an indicator of the degree of oxidation of methionine-148 residue in apolipoprotein-A1. Oxidation of apo-A1 in methionine-148, in turn, leads to an impaired maturation of high-density lipoproteins (HDL) that is reflected in a decline of large HDL particles. Notably, such metabolic alterations occur in the absence of impaired glucose tolerance, hyperglycemia and hypertriglyceridemia, and were partially restored after 18 months of treatment with a low-dose combination of pioglitazone, metformin and flutamide.
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SAMINO GENÉ, Sara, VINAIXA CREVILLENT, Maria, DÍAZ, Marta, BELTRAN, Antoni, RODRÍGUEZ, Miguel angel, MALLOL, Roger, HERAS, Mercedes, CABRÉ LLOBET, Anna, GARCÍA, Lorena, CANELA I CANELA, Núria, ZEGHER, Francis de, CORREIG BLANCHAR, Xavier, IBÁÑEZ TODA, Lourdes, YANES, Oscar. Metabolomics reveals impaired maturation of HDL particles in adolescents with hyperinsulinaemic androgen excess.. _Scientific Reports_. 2015. Vol. 5, núm. 11496. [consulta: 25 de març de 2026]. ISSN: 2045-2322. [Disponible a: https://hdl.handle.net/2445/105867]