The rs10993994 risk allele for prostate cancer results in clinically relevant changes in microseminoprotein-beta expression in tissue and urine

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dc.contributor.authorWhitaker, Hayley C.
dc.contributor.authorKote-Jarai, Zsofia
dc.contributor.authorRoss-Adams, Helen
dc.contributor.authorWarren, Anne Y.
dc.contributor.authorBurge, Johanna
dc.contributor.authorGeorge, Anne
dc.contributor.authorBancroft, Elizabeth K.
dc.contributor.authorJhavar, Sameer
dc.contributor.authorLeongamornlert, Daniel
dc.contributor.authorTymrakiewicz, Malgorzata
dc.contributor.authorSaunders, Edward J.
dc.contributor.authorPage, Elizabeth
dc.contributor.authorMitra, Anita
dc.contributor.authorMitchell, Gillian
dc.contributor.authorLindeman, Geoffrey J.
dc.contributor.authorEvans, D. Gareth
dc.contributor.authorBlanco Guillermo, Ignacio
dc.contributor.authorMercer, Catherine
dc.contributor.authorRubinstein, Wendy S.
dc.contributor.authorNeal, David E.
dc.date.accessioned2013-06-26T18:13:28Z
dc.date.available2013-06-26T18:13:28Z
dc.date.issued2010-10-13
dc.date.updated2013-06-26T18:13:28Z
dc.description.abstractMicroseminoprotein-beta (MSMB) regulates apoptosis and using genome-wide association studies the rs10993994 single nucleotide polymorphism in the MSMB promoter has been linked to an increased risk of developing prostate cancer. The promoter location of the risk allele, and its ability to reduce promoter activity, suggested that the rs10993994 risk allele could result in lowered MSMB in benign tissue leading to increased prostate cancer risk.
dc.format.extent8 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec595967
dc.identifier.issn1932-6203
dc.identifier.pmid20967219
dc.identifier.urihttps://hdl.handle.net/2445/44444
dc.language.isoeng
dc.publisherPublic Library of Science (PLoS)
dc.relation.isformatofReproducció del document publicat a: 10.1371/journal.pone.0013363
dc.relation.ispartofPLoS One, 2010, vol. 5, num. 10, p. e13363
dc.relation.urihttp://dx.doi.org/10.1371/journal.pone.0013363
dc.rightscc-by (c) Whitaker, Hayley C. et al., 2010
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es
dc.sourceArticles publicats en revistes (Patologia i Terapèutica Experimental)
dc.subject.classificationCàncer de pròstata
dc.subject.classificationOncogens
dc.subject.classificationMarcadors genètics
dc.subject.otherProstate cancer
dc.subject.otherOncogenes
dc.subject.otherGenetic markers
dc.titleThe rs10993994 risk allele for prostate cancer results in clinically relevant changes in microseminoprotein-beta expression in tissue and urine
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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