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2024-09-19

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cc-by-nc-nd (c) Chileshe, M. et al., 2024
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/227183

SARS-CoV-2 seroprevalence and preeclampsia markers in Mozambican pregnant women with perinatal loss.

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https://doi.org/10.1186/s12884-024-06800-9

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Background SARS-CoV-2 infection during pregnancy is known to be associated with poor pregnancy outcomes, including pre-eclampsia (PE), prematurity, perinatal and maternal mortality. Data on the burden of SARS-CoV-2 infection among pregnant women and their offspring in Sub-Saharan Africa is limited. We aimed to estimate SARS-CoV-2 seroprevalence and determine PE biomarkers in Mozambican pregnant women with perinatal loss. Methods A cross-sectional study was conducted among women who had a fetal or an early neonatal death at the Maputo Central Hospital (MCH), Mozambique. Anti-SARS-CoV-2 IgG/IgM were determined in maternal and umbilical cord blood and PE biomarkers (sFlt-1 and PIGF) in maternal blood. SARS-CoV-2 RT-PCR was performed in placenta and fetal lung biopsies from participants found to be SARS-CoV-2 seropositive. Results A total of 100 COVID-19 unvaccinated women were included in the study from March 2021 to April 2022. Total SARS-CoV-2 antibodies were detected in 68 [68%; 95CI (58 – 76)] maternal and 55 [55%; 95CI (54 – 74)] cord blood samples. SARS-CoV-2 IgM was detected in 18 cord blood samples and a positive placental RT-PCR in three of these participants. The proportion of women with moderate to high sFlt-1/PIGF ratio was higher in SARS-CoV-2 seropositive women than in those seronegative (71.2% vs 28.8%, p = 0.339), although the difference was not statistically significant. Conclusions SARS-CoV-2 seroprevalence among Mozambican women with perinatal loss was high during the second pandemic year, and there was evidence of vertical transmission in stillbirths. Findings also suggest that maternal SARS-CoV-2 infection may increase the risk of developing PE.

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Complicacions en l'embaràs, COVID-19, Marcadors bioquímics

Matèries (anglès)

Complications of pregnancy, COVID-19, Biochemical markers

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Articles publicats en revistes (Biomedicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (ISGlobal)

Citació

CHILESHE, Maureen, NHAMPOSSA, Tacilta, Carrilho Carla, MENDES, Anete, LUIS, Elvira, SACARLAL, Jahit, NAVERO CASTILLEJOS, Jessica, MORALES RUIZ, Manuel, MARTÍNEZ YOLDI, Miguel julián, ORDI I MAJÀ, Jaume, RAKISLOVA, Natalia, MENÉNDEZ, Clara, GONZÁLEZ ÁLVAREZ, Raquel. SARS-CoV-2 seroprevalence and preeclampsia markers in Mozambican pregnant women with perinatal loss.. _BMC Pregnancy and Childbirth_. 2024. Vol. 24, núm. 1. [consulta: 23 de febrer de 2026]. ISSN: 1471-2393. [Disponible a: https://hdl.handle.net/2445/227183]

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