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2025-02-12

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cc-by (c) Gutzeit, C et al., 2025
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/219500

Gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses

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https://doi.org/10.1126/sciadv.ado9455

Resum

The gut microbiota enhances systemic immunoglobulin G (IgG) responses to vaccines, but it is unknown whether this effect involves IgA, which coats intestinal microbes. That IgA may amplify postimmune IgG production is suggested by the impaired IgG response to pneumococcal vaccines in some IgA-deficient patients. Here, we found that antipneumococcal but not total IgG production was impaired in mice with IgA deficiency. The positive effect of gut IgA on antipneumococcal IgG responses started very early in life and could implicate gut bacteria, as these responses were attenuated in germ-free mice recolonized with gut microbes from IgA-deficient donors. IgA could exert this effect by constraining the systemic translocation of gut antigens, which was associated with chronic immune activation, including T cell overexpression of programmed cell death protein 1 (PD-1). This inhibitory receptor may attenuate antipneumococcal IgG production by causing B cell hyporesponsiveness, which improved upon anti-PD-1 treatment. Thus, gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses

Matèries

Immunoglobulina G, Microbiota intestinal, Immunoglobulina A, Vacuna antipneumocòccica

Matèries (anglès)

Immunoglobulin G, Gastrointestinal microbiome, Immunoglobulin A, Pneumococcal vaccine

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Articles publicats en revistes (Biomedicina)

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GUTZEIT, Cindy, GRASSET, Emilie k., MATTHEWS, Dean b., MAGLIONE, Paul j., BRITTON, Graham j., MILLER, Halley, MAGRI, Giuliana, TOMALIN, Lewis, STAPYLTON, Matthew, CANALES HERRERIAS, Pablo, SOMINSKAIA, Musia, GUZMAN, Mauricio, PYBUS, Marc, TEJEDOR VAQUERO, Sonia, RADIGAN, Lin, TACHÓ PIÑOT, Roser, MARTÍN NALDA, Andrea, GARCÍA PRAT, Marina, MARTÍNEZ GALLO, Mónica, DIELI CRIMI, Romina, CLEMENTE, José c., MEHANDRU, Saurabh, SUÁREZ FARINAS, Mayte, FAITH, Jeremiah j., CUNNINGHAM-RUNDLES, Charlotte, CERUTTI, Andrea. Gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses. _Science Advances_. 2025. Vol. 11, núm. 7. [consulta: 20 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/219500]

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