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Article

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2012-07-24

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/125422

Control of microenvironmental cues with a smart biomaterial composite promotes endothelial progenitor cell angiogenesis

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https://doi.org/10.22203/eCM.v024a07

Abstract

Abstract: Smart biomaterials play a key role when aiming at successful tissue repair by means of regenerative medicine approaches, and are expected to contain chemical as well as mechanical cues that will guide the regenerative process. Recent advances in the understanding of stem cell biology and mechanosensing have shed new light onto the importance of the local microenvironment in determining cell fate. Herein we report the biological properties of a bioactive, biodegradable calcium phosphate glass/polylactic acid composite biomaterial that promotes bone marrow-derived endothelial progenitor cell (EPC) mobilisation, differentiation and angiogenesis through the creation of a controlled bone healing-like microenvironment. The angiogenic response is triggered by biochemical and mechanical cues provided by the composite, which activate two synergistic cell signalling pathways: a biochemical one mediated by the calcium-sensing receptor and a mechanosensitive one regulated by non-muscle myosin II contraction. Together, these signals promote a synergistic response by activating EPCs-mediated VEGF and VEGFR-2 synthesis, which in turn promote progenitor cell homing, differentiation and tubulogenesis. These findings highlight the importance of controlling microenvironmental cues for stem/progenitor cell tissue engineering and offer exciting new therapeutical opportunities for biomaterial-based vascularisation approaches and clinical applications.

Subject

Materials intel·ligents, Nanopartícules, Enginyeria de teixits

Subject (English)

Smart materials, Nanoparticles, Tissue engineering

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Articles publicats en revistes (Enginyeria Electrònica i Biomèdica)

Citation

AGUIRRE, Aitor, et al. Control of microenvironmental cues with a smart biomaterial composite promotes endothelial progenitor cell angiogenesis. European Cells & Materials. 2012. Vol. 24, num. 90-106. ISSN 1473-2262. [consulted: 8 of June of 2026]. Available at: https://hdl.handle.net/2445/125422

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