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2025-07-02

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cc-by (c) César Jessé Enríquez-Rodríguez et al., 2025
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/227544

Metabolomic signatures predict seven-year mortality in clinically stable COPD patients

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https://doi.org/10.3390/ijms26136373

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Chronic Obstructive Pulmonary Disease (COPD) is a complex condition with high mortality. Early identification of patients at increased risk of death remains a major clinical challenge. This pilot study aimed to explore whether plasma metabolomic profiling could aid in the prediction of long-term (7-year) mortality and provide insight into potential underlying mechanisms. Plasma samples from 54 randomly selected stable COPD patients were analyzed using both untargeted and semi-targeted LC-MS approaches. After excluding patients with unclear death data, non-COPD-related deaths and metabolomic outliers, 41 individuals were included in the final analysis. During follow-up, 13 patients (32%) died, and 28 survived. Univariate analysis identified 12 metabolites—mainly amino acids—that differed significantly between the two groups. Functional analysis suggested a significant disruption in energy production pathways. Predictive models developed using machine learning algorithms, consisting of either ten metabolites alone or nine metabolites plus FEV1, achieved high accuracy for 7-year mortality prediction, with the latter model performing slightly better. Internal validation was conducted using five-fold cross-validation. While exploratory, these findings support the hypothesis that early metabolic alterations, particularly in energy pathways, may contribute to long-term mortality risk in stable COPD patients, and could complement traditional prognostic markers such as FEV1.

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Malalties pulmonars obstructives cròniques, Trastorns del metabolisme, Aminoàcids

Matèries (anglès)

Chronic obstructive pulmonary diseases, Disorders of metabolism, Amino acids

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ENRÍQUEZ RODRÍGUEZ, Cesar jesse, AGRANOVICH, Bella, PASCUAL GUÀRDIA, Sergi, FANER, Rosa, CAMPS UBACH, Ramon, CASTRO ACOSTA, Ady angélica, LÓPEZ CAMPOS, José luis, PECES BARBA, Germán, SEIJO MACEIRAS, Luis miguel, CAGUANA, Oswaldo antonio, RODRÍGUEZ CHIARADIA, Diego agustín, BARREIRO, Esther, MONSÓ, Eduard, COSÍO, Borja g., ABRAMOVICH, Ifat, AGUSTÍ GARCÍA-NAVARRO, Àlvar, CASADEVALL, Carme, GEA GUIRAL, Joaquim, BIOMEPOC Group. Metabolomic signatures predict seven-year mortality in clinically stable COPD patients. _International Journal of Molecular Sciences_. 2025. Vol. 26, núm. 13. [consulta: 9 de març de 2026]. ISSN: 1661-6596. [Disponible a: https://hdl.handle.net/2445/227544]

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