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656271.pdf (2.17 MB)

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2016-01-11

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cc-by (c) Reyes-Zurita, Fernando J. et al., 2016
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/104424

Maslinic acid, a natural Triterpene, induces a death receptor-mediated apoptotic mechanism in Caco-2 p53-deficient colon adenocarcinoma cells

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Recurs relacionat

https://doi.org/10.1371/journal.pone.0146178

Resum

Maslinic acid (MA) is a natural triterpene present in high concentrations in the waxy skin of olives. We have previously reported that MA induces apoptotic cell death via the mito- chondrial apoptotic pathway in HT29 colon cancer cells. Here, we show that MA induces apoptosis in Caco-2 colon cancer cells via the extrinsic apoptotic pathway in a dose- dependent manner. MA triggered a series of effects associated with apoptosis, including the cleavage of caspases -8 and -3, and increased the levels of t-Bid within a few hours of its addition to the culture medium. MA had no effect on the expression of the Bax protein, release of cytochrome-c or on the mitochondr ial membrane potential. This suggests that MA triggered the extrinsic apoptotic pathway in this cell type, as opposed to the intrinsic pathway found in the HT29 colon-cancer cell line. Our results suggest that the apoptotic mechanism induced in Caco-2 may be different from that found in HT29 colon-cancer cells, and that in Caco-2 cells MA seems to work independently of p53. Natural antitumoral agents capable of activating both the extrinsic and intrinsic apoptotic pathways could be of great use in treating colon-cancer of whatever origin.

Matèries

Olis vegetals, Càncer colorectal, Diferenciació cel·lular, Proteïnes

Matèries (anglès)

Vegetable oils, Colorectal cancer, Cell diferentiation, Proteins

Citació

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Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

Citació

REYES-ZURITA, Fernando j., RUFINO PALOMARES, Eva e., GARCÍA SALGUERO, Leticia, PERAGÓN, Juan, MEDINA, Pedro p., PARRA PUERTO, Andrés, CASCANTE I SERRATOSA, Marta, LUPIÁÑEZ, José a.. Maslinic acid, a natural Triterpene, induces a death receptor-mediated apoptotic mechanism in Caco-2 p53-deficient colon adenocarcinoma cells. _PLoS One_. 2016. Vol. 11, núm. 1, pàgs. e0146178. [consulta: 7 de gener de 2026]. ISSN: 1932-6203. [Disponible a: https://hdl.handle.net/2445/104424]

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