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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/57126
Thiopeptide antibiotics: retrospective and recent advances
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Thiopeptides, or thiazolyl peptides, are a relatively new family of antibiotics that already counts with more than one hundred different entities. Although they are mainly isolated from soil bacteria, during the last decade, new members have been isolated from marine samples. Far from being limited to their innate antibacterial activity, thiopeptides have been found to possess a wide range of biological properties, including anticancer, antiplasmodial, immunosuppressive, etc. In spite of their ribosomal origin, these highly posttranslationally processed peptides have posed a fascinating synthetic challenge, prompting the development of various methodologies and strategies. Regardless of their limited solubility, intensive investigations are bringing thiopeptide derivatives closer to the clinic, where they are likely to show their veritable therapeutic potential.
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JUST BARINGO, Xavier, ALBERICIO PALOMERA, Fernando and ÁLVAREZ DOMINGO, Mercedes. Thiopeptide antibiotics: retrospective and recent advances. Marine Drugs. 2014. Vol. 12, num. 1, pags. 317-351. ISSN 1660-3397. [consulted: 9 of October of 2026]. Available at: https://hdl.handle.net/2445/57126