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2022-11-03

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cc-by (c) Ramos Romero, Sara et al., 2022
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/192982

Fiber-like Action of D-Fagomine on the Gut Microbiota and Body Weight of Healthy Rats

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https://doi.org/10.3390/nu14214656

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The goal of this work is to explore if the changes induced by D-fagomine in the gut microbiota are compatible with its effect on body weight and inflammation markers in rats. Methods: Sprague Dawley rats were fed a standard diet supplemented with D-fagomine (or not, for comparison) for 6 months. The variables measured were body weight, plasma mediators of inflammation (hydroxyeicosatetraenoic acids, leukotriene B4, and IL-6), and the concentration of acetic acid in feces and plasma. The composition and diversities of microbiota in cecal content and feces were estimated using 16S rRNA metabarcoding and high-throughput sequencing. We found that after just 6 weeks of intake D-fagomine significantly reduced body weight gain, increased the plasma acetate concentration, and reduced the plasma concentration of the pro-inflammatory biomarkers' leukotriene B4, interleukin 6 and 12 hydroxyeicosatetraenoic acids. These changes were associated with a significantly increased prevalence of Bacteroides and Prevotella feces and increased Bacteroides, Prevotella, Clostridium, and Dysgonomonas while reducing Anaerofilum, Blautia, and Oribacterium in cecal content. In conclusion, D-fagomine induced changes in the composition and diversity of gut microbiota similar to those elicited by dietary fiber and compatible with its anti-inflammatory and body-weight-reducing effects.

Matèries

Inflamació, Pes corporal

Matèries (anglès)

Inflammation, Body weight

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Articles publicats en revistes (Enginyeria Química i Química Analítica)

Citació

RAMOS ROMERO, Sara, et al. Fiber-like Action of D-Fagomine on the Gut Microbiota and Body Weight of Healthy Rats. Nutrients. 2022. Vol. 14, num. 21, pags. 4656. ISSN 2072-6643. [consulted: 22 of May of 2026]. Available at: https://hdl.handle.net/2445/192982

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