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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/46846
Childhood adversity and psychosis: examinig whether the association is due to genetic confounding using a monozygotic twin differences approach
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Purpose: To test whether the association between childhood adversity and positive and negative psychotic experiences is due to genetic confounding. Method: Childhood adversity and psychotic experiences were assessed in a sample of 226 twins from the general population. A monozygotic (MZ) twin differences approach was used to assess possible genetic confounding. Results: In the whole sample, childhood adversity was significantly associated with positive (β =.45; SE=.16; p=.008) and negative psychotic experiences (β=.77; SE=.18; p<.01). Within-pair MZ twin differences in exposure to childhood adversity were significantly associated with differences in positive (β =.71; SE=.29; p=.016) and negative psychotic experiences (β =.98; SE=.38; p=.014) in a subsample of 86 MZ twin pairs. Conclusions: Individuals exposed to childhood adversity are more likely to report psychotic experiences. Furthermore, our findings indicate that unique environmental effects of childhood adversity contribute to the development of psychotic experiences.
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ALEMANY SIERRA, Silvia, GOLDBERG, Ximena, VAN WINKEL, Ruud, GASTÓ FERRER, Cristóbal, PERALTA, Víctor, FAÑANÁS SAURA, Lourdes. Childhood adversity and psychosis: examinig whether the association is due to genetic confounding using a monozygotic twin differences approach. _European Psychiatry_. 2013. Vol. 28, núm. 4, pàgs. 207-212. [consulta: 10 de desembre de 2025]. ISSN: 0924-9338. [Disponible a: https://hdl.handle.net/2445/46846]