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2021-09-30

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cc-by (c) Benítez, Leticia et al., 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/181200

The Contribution of QF-PCR and pathology studies in the diagnosis of diandric triploidy/partial mole

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https://doi.org/10.3390/diagnostics11101811

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Objective: the aim of our study was to assess the contribution of quantitative fluorescent polymerase chain reaction (QF-PCR) and pathology studies in the diagnosis of diandric triploidies/partial hydatidiform moles. Methods: this study included all fet al triploidies diagnosed by QF-PCR in chorionic villi or amniotic fluid in the 2 centers of BCNatal in which a maternal saliva sample was used to establish its parental origin. Pathology studies were performed in products of conception and concordance between a partial hydatidiform mole diagnosis and the finding of a diandric triploidy was assessed. Results: among 46 fetal triploidies, found in 13 ongoing pregnancies and in 33 miscarriages, there were 26 (56%) diandric triploidies. Concordant molecular (diandric triploidy) and pathology results (partial mole) were achieved in 14 cases (54%), while in 6 cases (23%) pathology studies were normal, and in the remaining 6 cases (23%) pathology studies could not be performed because miscarriage was managed medically. Conclusions: diandric triploidy is associated with partial hydatidiform mole and its diagnosis is crucial to prevent the development of persistent trophoblastic disease. QF-PCR analysis in chorionic villi or amniotic fluid provides a more accurate diagnosis of the parental origin of triploidy than the classical pathology studies

Matèries

Reacció en cadena de la polimerasa

Matèries (anglès)

Polymerase chain reaction

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Articles publicats en revistes (Fonaments Clínics)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

BENITEZ, Leticia, et al. The Contribution of QF-PCR and pathology studies in the diagnosis of diandric triploidy/partial mole. Diagnostics. 2021. Vol. 11, num. 10, pags. 1811. ISSN 2075-4418. [consulted: 23 of May of 2026]. Available at: https://hdl.handle.net/2445/181200

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