The state of Play with iPSCs and Spinal Cord Injury

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dc.contributor.authorHodgetts, S.I.
dc.contributor.authorEdel, Michael John
dc.contributor.authorHarvey, A.R.
dc.date.accessioned2015-07-16T08:12:37Z
dc.date.available2015-07-16T08:12:37Z
dc.date.issued2015-01-14
dc.date.updated2015-07-16T08:12:37Z
dc.description.abstractThe application of induced pluripotent stem cell (iPSC) technologies in cell based strategies, for the repair of the central nervous system (with particular focus on the spinal cord), is moving towards the potential use of clinical grade donor cells. The ability of iPSCs to generate donor neuronal, glial and astrocytic phenotypes for transplantation is highlighted here, and we review recent research using iPSCs in attempts to treat spinal cord injury in various animal models. Also discussed are issues relating to the production of clinical grade iPSCs, recent advances in transdifferentiation protocols for iPSC-derived donor cell populations, concerns about tumourogenicity, and whether iPSC technologies offer any advantages over previous donor cell candidates or tissues already in use as therapeutic tools in experimental spinal cord injury studies.
dc.format.extent11 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec653273
dc.identifier.issn2077-0383
dc.identifier.urihttps://hdl.handle.net/2445/66378
dc.language.isoeng
dc.publisherMDPI
dc.relation.isformatofReproducció del document publicat a: http://dx.doi.org/10.3390/jcm4010193
dc.relation.ispartofJournal of Clinical Medicine, 2015, vol. 4, p. 193-203
dc.relation.urihttp://dx.doi.org/10.3390/jcm4010193
dc.rightscc-by (c) Hodgetts, S.I. et al., 2015
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es
dc.sourceArticles publicats en revistes (Ciències Fisiològiques)
dc.subject.classificationCèl·lules mare
dc.subject.classificationLesions medul·lars
dc.subject.classificationSistema nerviós central
dc.subject.classificationTrasplantament d'òrgans
dc.subject.otherStem cells
dc.subject.otherSpinal cord injuries
dc.subject.otherCentral nervous system
dc.subject.otherTransplantation of organs
dc.titleThe state of Play with iPSCs and Spinal Cord Injury
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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