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2003-12

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/118990

Treatment of Chronic Hepatitis C in HIV-Infected Patients with Interferon α-2b Plus Ribavirin

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https://doi.org/10.1089/088922203771881176

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One hundred six HIV-infected patients with chronic hepatitis C virus (HCV) infection were randomized to receive ribavirin (RBV) 400 mg bid plus interferon α-2b (IFN-α) at two different doses, 3 mU tiw (control arm) or 5 mU daily for the first 6 weeks, followed by 3 mU tiw until completing 6 months of therapy (induction arm). All patients had CD4 counts above 350 cells/μl and 89% were taking antiretroviral therapy. Adverse effects leading to treatment discontinuation occurred in 12.3% of patients, a rate quite similar to that seen in HCV-monoinfected patients. Negative serum HCV-RNA values (<60 IU/ml) were recorded in 24.7% and 35.5% of patients at 3 and 6 months of therapy. However, in the intent-to-treat analysis, sustained response was reached by only 16% of patients (22.4% in the on-treatment analysis). No differences between treatment arms were noticed. Patients with HCV genotypes 2 or 3 had a 7-fold higher response rate than those with HCV genotypes 1 or 4. Therefore, early, end-of-treatment, and sustained response rates are lower in HIV/HCV-coinfected patients treated with RBV/IFN-α combination therapy. Since HCV-related liver disease is currently one of the leading causes of morbidity and mortality among HIV-infected patients, new treatment options are urgently needed for coinfected individuals.

Matèries

Hepatitis C, Interferó, Efecte dels medicaments sobre els microorganismes, Medicaments antivírics, Infeccions per VIH

Matèries (anglès)

Hepatitis C, Interferon, Effect of drugs on microorganisms, Antiviral agents, HIV infections

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PÉREZ-OLMEDA, Mayte, SORIANO, Vincent, ASENSI, Victor, MORALES, Dolores, ROMERO, Miriam, OCHOA, Anna, SÁNCHEZ-MONTERO, Fausto, SANTÍN CEREZALES, Miguel, GUARDIOLA, Josep, BLANCH, Jesús, NÚÑEZ, Marina, JIMÉNEZ-NÁCHER, Inmaculada, GARCÍA-SAMANIEGO, Javier, HCV/HIV Spanish Study Team. Treatment of Chronic Hepatitis C in HIV-Infected Patients with Interferon α-2b Plus Ribavirin. _Aids Research and Human Retroviruses_. 2003. Vol. 19, núm. 12, pàgs. 1083-1089. [consulta: 23 de gener de 2026]. ISSN: 0889-2229. [Disponible a: https://hdl.handle.net/2445/118990]

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