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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/120654
Tumour-marker levels and prognosis in malignant teratoma of the testis
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The effect of 6 putative prognostic factors on survival was studied in patients with Stages III and IV malignant teratoma of the testis. Differences between survival curves were tested for statistical significance. A diameter greater than 5 cm in the largest tumour mass, and greater than 8 pulmonary metastases were adverse prognostic factors (P = 0.004 and 0.008 respectively). Patients with malignant teratoma, trophoblastic, fared worse than those with malignant teratoma, undifferentiated, and malignant teratoma, intermediate (P = 0.011 and 0.023 respectively). Previous chemotherapy or radiotherapy had no significant effect. Serum alpha-foetoprotein (AFP) above 10(3) MRC u/ml and serum beta subunit of human chorionic gonadotrophin (hCG) above 10(5) miu/ml, were found to predict a poor prognosis (P = 0.010 and 0.001 respectively). A combination of measurements of the tumour markers gave the most consistent indication of prognosis, in that patients with either AFP greater than 10(3) MRC u/ml or hCG greater than 10(5) miu/ml, or both, fared much worse than those with neither factor (P = 0.001). Serum concentrations of AFP and hCG should be stated in reports of treatment of testicular teratoma in order to provide a basis for comparison with other series. Regular and frequent measurements of these markers are appropriate throughout the clinical management of patients with malignant teratoma.
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GERMÀ LLUCH, José Ramón, BEGENT, R. H. J. and BAGSHAWE, K. D. Tumour-marker levels and prognosis in malignant teratoma of the testis. British Journal of Cancer. 1980. Vol. 42, num. 6, pags. 850-855. ISSN 0007-0920. [consulted: 16 of June of 2026]. Available at: https://hdl.handle.net/2445/120654