Carregant...
Fitxers
Tipus de document
TesiVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/204049
Study of immune population infiltrated in white adipose tissue: Novel target genes in obesity and metabolic diseases
Títol de la revista
Autors
Director/Tutor
ISSN de la revista
Títol del volum
Resum
[eng] Obesity is a chronic condition, with a multifactorial etiology whose incidence has tripled in the last four decades. This condition is associated with a low-grade inflammation caused by an activation of the proinflammatory response of immune cells WAT-infiltrating, which can lead to different comorbidities, directly affecting life expectancy.
WAT is the main organ responsible for energy storage, in the form of lipids. But also act as an endocrine organ being able to respond to metabolic changes. Therefore, it promotes changes in whole metabolism leading to the development of IR and an increased cardiometabolic risk. Additionally, the WAT is distributed into two depots: SAT and VAT, each with its own biochemical features and metabolic functions. It has been described that SAT has a protective role it is inversely associated with glucose intolerance, IR, and risk of T2D diagnosis. At the same time VAT is linked with a worsening of metabolic status.
WAT is an organ composed by heterogeneous population of cells including pre-adipocytes, fibroblasts, endothelial cells, stem cells and immune cells which changes according to metabolic status. The immune cells regulate WAT function, which is disrupted in obesity, promoting inflammatory signalling which lead to inflammatory, hypoxic, and fibrotic events in WAT. Because the WAT-infiltrated macrophages are the most abundant immune population in WAT, its contribute to a highest proportion to the disruption of homeostasis in obese WAT.
However, little is known about which genes or pathways are altered in whole VAT compared to SAT, which promote the development of metabolic diseases. For thus, the objective of this work was determining gene targets that contribute to a worse metabolic prognosis to find its possible role in the development of obesity, related with each depot and infiltrating macrophages.
We show for the first time that the phenotype of macrophages infiltrating in WAT have a different gene expression profile according to the depot. Our work proposes novel targets involved in obesity and related metabolic diseases.
Descripció
Matèries
Matèries (anglès)
Citació
Citació
REYES FARÍAS, Marjorie. Study of immune population infiltrated in white adipose tissue: Novel target genes in obesity and metabolic diseases. [consulta: 7 de desembre de 2025]. [Disponible a: https://hdl.handle.net/2445/204049]