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2019-08-03

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cc-by-nc-nd (c) Nicolás, David et al., 2019
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/161478

Prevalence, clinical characteristics and outcome of severe primary HIV-1 infection: a prospective cohort study

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https://doi.org/10.1016/j.ijid.2019.08.001

Abstract

Background: Severe cases of primary HIV infection have been described in patients presenting with neurological involvement, AIDS defining events or other life-threatening events. These severe forms have not been fully studied. Objectives: To determine the prevalence and characteristics of severe PHI in a hospital-based cohort of primary HIV infection, and the response to the early initiation of antiretroviral therapy (ART) at 12 months. Methods: Every patient with PHI attending Hospital Clínic of Barcelona (1997-2015) was evaluated. Severe PHI was defined using clinical, analytical and immunological criteria. Chi-squared test was used for categorical variables and Student's t-test for quantitative variables. Results: 33% of 224 PHI patients (95% CI: 26.84%-39.16%) had a severe PHI. These patients had more symptoms, abnormal analytical parameters and hospital admissions. The severe PHI group had a significantly higher viral load although no differences were observed at 12 months in terms of viral suppression or CD4 count recovery. None died during PHI. Conclusions: Up to one third of patients in our cohort presented with a severe PHI, which was associated with higher hospitalization rates and higher plasma HIV RNA viral load. However, severe forms were not associated to a worse clinical, immunological or virological outcome at 12 months.

Subject

Infeccions per VIH, Pacients amb lesions cerebrals, Antiretrovirals

Subject (English)

HIV infections, Brain damage patients, Antiretroviral agents

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Articles publicats en revistes (Fonaments Clínics)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citation

NICOLÁS, David, et al. Prevalence, clinical characteristics and outcome of severe primary HIV-1 infection: a prospective cohort study. International Journal of Infectious Diseases. 2019. Vol. 88, num. 73-79. ISSN 1201-9712. [consulted: 16 of August of 2026]. Available at: https://hdl.handle.net/2445/161478

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