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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/161478
Prevalence, clinical characteristics and outcome of severe primary HIV-1 infection: a prospective cohort study
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Background: Severe cases of primary HIV infection have been described in patients presenting with neurological involvement, AIDS defining events or other life-threatening events. These severe forms have not been fully studied. Objectives: To determine the prevalence and characteristics of severe PHI in a hospital-based cohort of primary HIV infection, and the response to the early initiation of antiretroviral therapy (ART) at 12 months. Methods: Every patient with PHI attending Hospital Clínic of Barcelona (1997-2015) was evaluated. Severe PHI was defined using clinical, analytical and immunological criteria. Chi-squared test was used for categorical variables and Student's t-test for quantitative variables. Results: 33% of 224 PHI patients (95% CI: 26.84%-39.16%) had a severe PHI. These patients had more symptoms, abnormal analytical parameters and hospital admissions. The severe PHI group had a significantly higher viral load although no differences were observed at 12 months in terms of viral suppression or CD4 count recovery. None died during PHI. Conclusions: Up to one third of patients in our cohort presented with a severe PHI, which was associated with higher hospitalization rates and higher plasma HIV RNA viral load. However, severe forms were not associated to a worse clinical, immunological or virological outcome at 12 months.
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NICOLÁS, David, SUÁREZ, Antonio, AMBROSIONI, Juan, MANZARDO, Christian, LIGERO, Carmen, COSTA, Josep, FERNÁNDEZ, Emma, MARCOS, Ma. angeles, PLANA PRADES, Montserrat, MOSQUERA, Maria mar, SÁNCHEZ-PALOMINO, Sonsoles, GATELL, José m., MIRÓ MEDA, José m. (josé maría). Prevalence, clinical characteristics and outcome of severe primary HIV-1 infection: a prospective cohort study. _International Journal of Infectious Diseases_. 2019. Vol. 88, núm. 73-79. [consulta: 30 de gener de 2026]. ISSN: 1201-9712. [Disponible a: https://hdl.handle.net/2445/161478]