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Host-Derived Molecules as Novel Chagas Disease Biomarkers: Hypercoagulability Markers in Plasma
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The most severe clinical symptomatology of Chagas disease
affects ~30% of those chronically infected with the Trypanosoma
cruzi parasite. The pathogenic mechanisms that lead to
life-threatening heart and gut tissue disruptions occur
"silently" for a longtime in a majority of cases. As a result,
despite there are several serological and molecular methods
available to diagnose the infection in its acute and chronic
stages, diagnosis is often achieved only after the onset of
clinical symptoms in the chronic phase of the disease.
Furthermore, although there are two drugs to treat it, the
assessment of their performance is impractical with current
parasite-derived diagnostics, and therapeutic efficacy cannot be
acknowledged in a timely manner.In this chapter we present two
procedures to measure host-derived molecules as surrogates of
therapeutic response against chronic T. cruzi infection. Their
outputs relate to the generation and activity of thrombin, a
major component of the blood coagulation cascade. This is due to
the fact that a hypercoagulability state has been described to
occur in chronic Chagas disease patients and revert after
treatment with benznidazole.
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ALONSO PADILLA, Julio, TÀSSIES PENELLA, María dolores, CORTÉS SERRA, Núria, GASCÓN I BRUSTENGA, Joaquim, REVERTER CALATAYUD, Juan carlos, PINAZO, Maria-jesus. Host-Derived Molecules as Novel Chagas Disease Biomarkers:
Hypercoagulability Markers in Plasma. _Methods in Molecular Biology_. 2019. Vol. 1955. [consulta: 20 de gener de 2026]. ISSN: 1064-3745. [Disponible a: https://hdl.handle.net/2445/170050]