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2025-12-01

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cc-by (c) Perucca, A. et al., 2025
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/219463

Micro Immune Response On-chip (MIRO) models the tumour-stroma interface for immunotherapy testing

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https://doi.org/10.1038/s41467-025-56275-1

Abstract

Immunotherapies are beneficial for a considerable proportion of cancer patients, but ineffective in others. In vitro modelling of the complex interactions between cancer cells and their microenvironment could provide a path to understanding immune therapy sensitivity and resistance. Here we develop MIRO, a fully humanised in vitro platform to model the spatial organisation of the tumour/stroma interface and its interaction with immune cells. We find that stromal barriers are associated with immune exclusion and protect cancer cells from antibody-dependent cellular cytotoxicity, elicited by targeted therapy. We demonstrate that IL2-driven immunomodulation increases immune cell velocity and spreading to overcome stromal immunosuppression and restores anti-cancer response in refractory tumours. Collectively, our study underscores the translational value of MIRO as a powerful tool for exploring how the spatial organisation of the tumour microenvironment shapes the immune landscape and influences the responses to immunomodulating therapies.

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Tumors, Cultiu cel·lular, Immunoteràpia, Càncer

Subject (English)

Tumors, Cell culture, Immunotheraphy, Cancer

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Articles publicats en revistes (Biomedicina)
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))

Citation

PERUCCA, Alice, et al. Micro Immune Response On-chip (MIRO) models the tumour-stroma interface for immunotherapy testing. Nature Communications. 2025. Vol. 16, num. 1. ISSN 2041-1723. [consulted: 12 of August of 2026]. Available at: https://hdl.handle.net/2445/219463

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