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2025-12-01

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cc-by (c) Perucca, A. et al., 2025
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/219463

Micro Immune Response On-chip (MIRO) models the tumour-stroma interface for immunotherapy testing

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Recurs relacionat

https://doi.org/10.1038/s41467-025-56275-1

Resum

Immunotherapies are beneficial for a considerable proportion of cancer patients, but ineffective in others. In vitro modelling of the complex interactions between cancer cells and their microenvironment could provide a path to understanding immune therapy sensitivity and resistance. Here we develop MIRO, a fully humanised in vitro platform to model the spatial organisation of the tumour/stroma interface and its interaction with immune cells. We find that stromal barriers are associated with immune exclusion and protect cancer cells from antibody-dependent cellular cytotoxicity, elicited by targeted therapy. We demonstrate that IL2-driven immunomodulation increases immune cell velocity and spreading to overcome stromal immunosuppression and restores anti-cancer response in refractory tumours. Collectively, our study underscores the translational value of MIRO as a powerful tool for exploring how the spatial organisation of the tumour microenvironment shapes the immune landscape and influences the responses to immunomodulating therapies.

Matèries

Tumors, Cultiu cel·lular, Immunoteràpia, Càncer

Matèries (anglès)

Tumors, Cell culture, Immunotheraphy, Cancer

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Col·leccions

Articles publicats en revistes (Biomedicina)
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))

Citació

PERUCCA, Alice, GÓMEZ LLONÍN, Andrea, MAÑÉ BENACH, Oriol, HALLOPEAU, Clement, RIVAS, Elisa i., LINARES, Jenniffer, GARRIDO, Marta, SALLENT ARAGAY, Anna, GOLDE, Tom, COLOMBELLI, Julien, DALAKA, Eleni, LINACERO, Judith, CAZORLA, Marina, GALAN, Teresa, PASTOR VIEL, Jordi, BADENAS, Xavier, RECORT-BASCUAS, A., COMERMA, Laura, FERNÁNDEZ NOGUEIRA, Patricia, ROVIRA, Ana, ROCA-CUSACHS SOULERE, Pere, ALBANELL MESTRES, Joan, TREPAT GUIXER, Xavier, CALON, Alexandre, LABERNADIE, Anna. Micro Immune Response On-chip (MIRO) models the tumour-stroma interface for immunotherapy testing. _Nature Communications_. 2025. Vol. 16, núm. 1. [consulta: 21 de gener de 2026]. ISSN: 2041-1723. [Disponible a: https://hdl.handle.net/2445/219463]

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