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Article

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Accepted version

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2019-08-01

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/178767

Integrins as biomechanical sensors of the microenvironment

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https://doi.org/10.1038/s41580-019-0134-2

Abstract

Integrins, and integrin-mediated adhesions, have long been recognized to provide the main molecular link attaching cells to the extracellular matrix (ECM) and to serve as bidirectional hubs transmitting signals between cells and their environment. Recent evidence has shown that their combined biochemical and mechanical properties also allow integrins to sense, respond to and interact with ECM of differing properties with exquisite specificity. Here, we review this work first by providing an overview of how integrin function is regulated from both a biochemical and a mechanical perspective, affecting integrin cell-surface availability, binding properties, activation or clustering. Then, we address how this biomechanical regulation allows integrins to respond to different ECM physicochemical properties and signals, such as rigidity, composition and spatial distribution. Finally, we discuss the importance of this sensing for major cell functions by taking cell migration and cancer as examples.

Subject

Nanociència, Matriu extracel·lular, Integrines

Subject (English)

Nanoscience, Extracellular matrix, Integrins

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Articles publicats en revistes (Biomedicina)
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))

Citation

KECHAGIA, Jenny Z., IVASKA, Johanna and ROCA-CUSACHS SOULERE, Pere. Integrins as biomechanical sensors of the microenvironment. Nature Reviews Molecular Cell Biology. 2019. Vol. 20, num. 8, pags. 457-473. ISSN 1759-5029. [consulted: 8 of August of 2026]. Available at: https://hdl.handle.net/2445/178767

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