Fitxers
Tipus de document
ArticleVersió
Versió acceptadaData de publicació
Tots els drets reservats
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/178767
Integrins as biomechanical sensors of the microenvironment
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Integrins, and integrin-mediated adhesions, have long been recognized to provide the main molecular link attaching cells to the extracellular matrix (ECM) and to serve as bidirectional hubs transmitting signals between cells and their environment. Recent evidence has shown that their combined biochemical and mechanical properties also allow integrins to sense, respond to and interact with ECM of differing properties with exquisite specificity. Here, we review this work first by providing an overview of how integrin function is regulated from both a biochemical and a mechanical perspective, affecting integrin cell-surface availability, binding properties, activation or clustering. Then, we address how this biomechanical regulation allows integrins to respond to different ECM physicochemical properties and signals, such as rigidity, composition and spatial distribution. Finally, we discuss the importance of this sensing for major cell functions by taking cell migration and cancer as examples.
Matèries
Matèries (anglès)
Citació
Citació
KECHAGIA, Jenny Z., IVASKA, Johanna and ROCA-CUSACHS SOULERE, Pere. Integrins as biomechanical sensors of the microenvironment. Nature Reviews Molecular Cell Biology. 2019. Vol. 20, num. 8, pags. 457-473. ISSN 1759-5029. [consulted: 27 of May of 2026]. Available at: https://hdl.handle.net/2445/178767