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2015-01-29

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/68592

Serotonin is involved in the psychostimulant and hypothermic effect of 4-methylamphetamine in rats.

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Recurs relacionat

http://dx.doi.org/10.1016/j.neulet.2015.01.075

Resum

4-Methylamphetamine (4-MA) has recently emerged as a designer drug of abuse in Europe and it is consumed always with amphetamine. There have been reported some deaths and non-fatal intoxications related to 4-MA. We investigated the changes in locomotor activity and body temperature after 4-MA administration to male Sprague-Dawley rats. Our experiments were carried out at a normal or high ambient temperature. 4-MA (2.5-10 mg/Kg, given subcutaneously) increased, in a dose-dependent manner, the horizontal locomotor activity that was significantly reduced by ketanserin, p-cholorophenylalanine (pCPA) or haloperidol, but not by pindolol. In addition, we have studied the effect of 4-MA on core body temperature by means of an implanted electronic thermograph, enabling continuous measurement of body temperature. We observed a dose-dependent hypothermic response to 4-MA that reached a maximum 45 min after a single injection. We also evidenced slight tachyphylaxis to the hypothermic effect when 4-MA was administered four times in a 2 h interval. The pre-treatment of animals with pCPA or pindolol, but not with ketanserin, fully abolished the hypothermic effect of 4-MA. With all that, we conclude that hypothermia induced by 4-MA is due to the release of 5-HT which activates postsynaptic 5-HT1A receptors.

Matèries

Amfetamines, Farmacologia, Hipotèrmia, Sistema nerviós central, Serotonina

Matèries (anglès)

Amphetamines, Pharmacology, Hypothermia, Central nervous system, Serotonin

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Col·leccions

Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
Articles publicats en revistes (Institut de Biomedicina (IBUB))

Citació

RUBIO, Mar, et al. Serotonin is involved in the psychostimulant and hypothermic effect of 4-methylamphetamine in rats. Neuroscience Letters. 2015. Vol. 590, num. 68-73. ISSN 0304-3940. [consulted: 5 of August of 2026]. Available at: https://hdl.handle.net/2445/68592

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