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937366.pdf (4.43 MB)

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2026-05-06

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cc by (c) Vilaseca, Antoni et al., 2026
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/229610

Nanomotor-Assisted Intravesical Chemotherapy for Bladder Tumor Reduction and Suppression of Early Tumor Regrowth

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Recurs relacionat

https://doi.org/10.1021/acs.nanolett.5c05411

Resum

Nanoparticles are widely used in nanomedicine for controlled drug delivery and improved bioavailability. However, their effectiveness is often limited by passive diffusion, especially in confined, fluid-filled environments like the bladder, where rapid drug clearance and uneven distribution reduce therapeutic impact. These challenges contribute to high recurrence in bladder cancer despite intravesical chemotherapy. To address this limitation, we present urease-powered nanomotors (NM) based on mesoporous silica nanoparticles loaded with Mitomycin C (MMC), the standard chemotherapeutic for nonmuscleinvasive bladder cancer. These NM useurea present in urine to induce motion and drug dispersion. In vitro, NM showed 2.3-fold higher uptake in mouse bladder cancer cells than passive nanoparticles and achieved the efficacy of free MMC (577.5 μg/mL) at a 20-fold lower dose (30 μg/mL). In vivo, a single intravesical dose reduced tumor volumes by 83% and prevented early tumor regrowth, demonstrating the potential of NM-based delivery for bladder cancer therapy.

Matèries

Proteïnes supressores de tumors, Tractament adjuvant del càncer

Matèries (anglès)

Tumor suppressor protein, Adjuvant treatment of cancer

Citació

Col·leccions

Articles publicats en revistes (Bioquímica i Fisiologia)
Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))

Citació

VILASECA, Antoni, et al. Nanomotor-Assisted Intravesical Chemotherapy for Bladder Tumor Reduction and Suppression of Early Tumor Regrowth. Nano Letters. 2026. Vol. 26, num. 17, pags. 5618-5627. ISSN 1530-6984. [consulted: 3 of August of 2026]. Available at: https://hdl.handle.net/2445/229610

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