SCOTfluors: Small, Conjugatable, Orthogonal, and Tunable Fluorophores for In Vivo Imaging of Cell Metabolism

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dc.contributor.authorBenson, Sam
dc.contributor.authorFernandez, Antonio
dc.contributor.authorBarth, Nicole D.
dc.contributor.authorde Moliner, Fabio
dc.contributor.authorHorrocks, Mathew H.
dc.contributor.authorHerrington, C. Simon
dc.contributor.authorAbad, José Luis
dc.contributor.authorDelgado Cirilo, Antonio
dc.contributor.authorKelly, Lisa
dc.contributor.authorChang, Ziyuan
dc.contributor.authorFeng, Yi
dc.contributor.authorNishiure, Miyako
dc.contributor.authorHori, Yuichiro
dc.contributor.authorKikuchi, Kazuya
dc.contributor.authorVendrell, Marc
dc.date.accessioned2020-11-09T15:16:15Z
dc.date.available2020-11-09T15:16:15Z
dc.date.issued2019-03-28
dc.date.updated2020-11-09T15:16:15Z
dc.description.abstractThe transport and trafficking of metabolites are critical for the correct functioning of live cells. However, in situ metabolic imaging studies are hampered by the lack of fluorescent chemical structures that allow direct monitoring of small metabolites under physiological conditions with high spatial and temporal resolution. Herein, we describe SCOTfluors as novel small‐sized multi‐colored fluorophores for real‐time tracking of essential metabolites in live cells and in vivo and for the acquisition of metabolic profiles from human cancer cells of variable origin.
dc.format.extent5 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec691691
dc.identifier.issn1433-7851
dc.identifier.pmid30924239
dc.identifier.urihttps://hdl.handle.net/2445/171908
dc.language.isoeng
dc.publisherWiley-VCH
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1002/anie.201900465
dc.relation.ispartofAngewandte Chemie-International Edition, 2019, vol. 58, num. 21, p. 6911-6915
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/771443/EU//DYNAFLUORS
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/704912/EU//FLUORODRUGS
dc.relation.urihttps://doi.org/10.1002/anie.201900465
dc.rightscc-by (c) Benson et. al., 2019
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.sourceArticles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
dc.subject.classificationMetabòlits
dc.subject.classificationCèl·lules canceroses
dc.subject.classificationMotilitat cel·lular
dc.subject.otherMetabolites
dc.subject.otherCancer cells
dc.subject.otherCell motility
dc.titleSCOTfluors: Small, Conjugatable, Orthogonal, and Tunable Fluorophores for In Vivo Imaging of Cell Metabolism
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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