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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/175889
Direct detection of molecular intermediates from first-passage times
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All natural phenomena are governed by energy landscapes. However, the direct measurement of this fundamen-tal quantity remains challenging, particularly in complex systems involving intermediate states. Here, we uncover key details of the energy landscapes that underpin a range of experimental systems through quantitative analysis of first-passage time distributions. By combined study of colloidal dynamics in confinement, transport through a biological pore, and the folding kinetics of DNA hairpins, we demonstrate conclusively how a short-time, power-law regime of the first-passage time distribution reflects the number of intermediate states associated with each of these processes, despite their differing length scales, time scales, and interactions. We thereby establish a powerful method for investigating the underlying mechanisms of complex molecular processes.
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THORNEYWORK, Alice l., GLADROW, J., QING, Yujia, RICO PASTÓ, Marc, RITORT FARRAN, Fèlix, BAYLEY, Hagan, KOLOMEISKY, Anatoly b., KEYSER, U.f.. Direct detection of molecular intermediates from first-passage times. _Science Advances_. 2020. Vol. 6, núm. 18, pàgs. eaaz4642. [consulta: 20 de gener de 2026]. ISSN: 2375-2548. [Disponible a: https://hdl.handle.net/2445/175889]