Amb motiu del tancament d'estiu, la validació de documents es reprendrà a partir del 28 d'agost de 2026. Disculpeu les molèsties.
Con motivo del cierre de verano, la validación de documentos se reanudará a partir del 28 de agosto de 2026. Disculpad las molestias
Due to the summer closure, document validation will resume starting August 28, 2026. We apologize for any inconvenience.

Files

607563.pdf (628.32 KB)

Document type

Article

Version

Accepted version

Publication date

2012-04-10

All rights reserved

Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/32351

pH Sensitive surfactants from lysine: assessment of their cytotoxicity and environmental behavior

Journal Title

Authors

Director/Tutor

Journal ISSN

Volume Title

Related resource

http://dx.doi.org/10.1021/la203974f

Abstract

The toxicity and environmental behavior of new pH-sensitive surfactants from lysine are presented. Three different chemical structures are studied: surfactants with one amino acid and one alkyl chain, surfactants with two amino acids on the polar head and one alkyl chain, and gemini surfactants. The pH sensitivity of these compounds can be tuned by modifying their chemical structures. Cytotoxicity has been evaluated using erythrocytes and fibroblast cells. The toxic effects against these cells depend on the hydrophobicity of the molecules as well as their cationic charge density. The effect of hydrophobicity and cationic charge density on toxicity is different for each type of cells. For erythrocytes, the toxicity increases as hydrophobicity and charge density increases. Nevertheless, for fibroblasts cationic charge density affects cytotoxicity in the opposite way: the higher charge density, the lower the toxicity. The effect of the pH on hemolysis has been evaluated in detail. The aquatic toxicity was established using Daphnia magna. All surfactants yielded EC50 values considerably higher than that reported for cationic surfactants based on quaternary ammonium groups. Finally, their biodegradability was evaluated using the CO2 headspace test (ISO 14593). These lysine derivatives showed high levels of biodegradation under aerobic conditions and can be classified as"readily biodegradable compounds".

Subject

Toxicologia, Aminoàcids, Agents tensioactius, Concentració dels ions d'hidrogen

Subject (English)

Toxicology, Amino acids, Surface active agents, Hydrogen-ion concentration

Citation

Collections

Articles publicats en revistes (Bioquímica i Fisiologia)

Citation

COLOMER FLORES, Aurora, et al. pH Sensitive surfactants from lysine: assessment of their cytotoxicity and environmental behavior. Langmuir. 2012. Vol. 28, num. 14, pags. 5900-5912. ISSN 0743-7463. [consulted: 11 of August of 2026]. Available at: https://hdl.handle.net/2445/32351

Export metadata

JSON - METS

Share record