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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/217272
Five latent factors underlie response to immunotherapy
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Only a subset of patients treated with immune checkpoint inhibitors (CPIs) respond to the treatment, and distinguishing responders from non-responders is a major challenge. Many proposed biomarkers of CPI response and survival probably represent alternative measurements of the same aspects of the tumor, its microenvironment or the host. Thus, we currently ignore how many truly independent biomarkers there are. With an unbiased analysis of genomics, transcriptomics and clinical data of a cohort of patients with metastatic tumors (n = 479), we discovered five orthogonal latent factors: tumor mutation burden, T cell effective infiltration, transforming growth factor-beta activity in the microenvironment, prior treatment and tumor proliferative potential. Their association with CPI response and survival was observed across all tumor types and validated across six independent cohorts (n = 1,491). These five latent factors constitute a frame of reference to organize current and future knowledge on biomarkers of CPI response and survival.
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USSET, Joseph, ROSENDAHL HUBER, Axel, ANDRIANOVA, Maria, BATLLE GÓMEZ, Eduard, CARLES, Joan, CUPPEN, Edwin, ELEZ, Elena, FELIP, Enriqueta, GÓMEZ REY, Marina, LO GIACCO, Deborah, MARTÍNEZ JIMÉNEZ, Francisco, MUÑOZ COUSELO, Eva, SIU, Lillian l., TABERNERO, Josep, VIVANCOS, Ana, MUIÑOS BALLESTER, Ferran, GONZALEZ PEREZ, Abel david, LÓPEZ BIGAS, Núria. Five latent factors underlie response to immunotherapy. _Nature Genetics_. 2024. Vol. vol 56, núm. 2112-2120. [consulta: 23 de gener de 2026]. ISSN: 1546-1718. [Disponible a: https://hdl.handle.net/2445/217272]