Impact of HIV kick-and-kill therapy on host epigenetic and transcriptional programs in PBMC, and viral rebound after cART interruption

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dc.contributor.authorOriol-Tordera, Bruna
dc.contributor.authorEsteve-Codina, Anna
dc.contributor.authorBerdasco, María
dc.contributor.authorGonçalves, Elena
dc.contributor.authorEsteller, Manel
dc.contributor.authorHanke, Tomá
dc.contributor.authorMoltó, José
dc.contributor.authorClotet, Bonaventura, 1953-
dc.contributor.authorCalle, María Luz
dc.contributor.authorCombadiere, Behazine
dc.contributor.authorSànchez, Àlex (Sànchez Pla)
dc.contributor.authorMothe, Beatriz
dc.contributor.authorRuiz-Riol, Marta
dc.contributor.authorBrander, Christian
dc.date.accessioned2023-05-16T14:18:12Z
dc.date.available2023-05-16T14:18:12Z
dc.date.issued2021-01-01
dc.date.updated2023-05-16T14:18:12Z
dc.description.abstractBackground: BCN02 was a pilot kick-and-kill clinical trial that combined therapeutic vaccination (MVA.HIVconsv) with the latency reversing agent romidepsin (RMD) followed by a monitored antiretroviral pause (MAP) in 15 early-treated HIV+ individuals (NCT02616874). Out of 12 evaluable participants for an omics subanalysis, 8 participants showed early (pVL > 2000 copies/mL < 4 weeks) and 4 a more delayed viral rebound (pVL > 2000 copies/mL > 4 weeks) in MAP. Systems biology analyses identified epigenetic and molecular mechanisms associated with response to vaccination and RMD and viral rebound kinetics.
dc.format.extent3 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec720636
dc.identifier.issn1758-2652
dc.identifier.urihttps://hdl.handle.net/2445/198070
dc.language.isoeng
dc.publisherBioMed Central
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1002/jia2.25659
dc.relation.ispartofJournal of the International AIDS Society, 2021, vol. 24, num. S1, p. 36-38
dc.relation.urihttps://doi.org/10.1002/jia2.25659
dc.rightscc-by (c) Oriol-Tordera, Bruna et al., 2021
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceArticles publicats en revistes (Genètica, Microbiologia i Estadística)
dc.subject.classificationVIH (Virus)
dc.subject.classificationEpigenètica
dc.subject.otherHIV (Viruses)
dc.subject.otherEpigenetics
dc.titleImpact of HIV kick-and-kill therapy on host epigenetic and transcriptional programs in PBMC, and viral rebound after cART interruption
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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