El CRAI romandrà tancat del 24 de desembre de 2025 al 6 de gener de 2026. La validació de documents es reprendrà a partir del 7 de gener de 2026.
El CRAI permanecerá cerrado del 24 de diciembre de 2025 al 6 de enero de 2026. La validación de documentos se reanudará a partir del 7 de enero de 2026.
From 2025-12-24 to 2026-01-06, the CRAI remain closed and the documents will be validated from 2026-01-07.
 
Miniatura

Fitxers

697249.pdf (1.48 MB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2019-10-09

Llicència de publicació

cc-by (c) Plas, Rogier L. C. et al., 2019
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/158541

A diet rich in fish oil and Leucine Ameliorates Hypercalcemia in tumour-induced cachectic mice

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.3390/ijms20204978

Resum

Background: Dietary supplementation with leucine and fish oil rich in omega-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) has previously been shown to reduce cachexia-related outcomes in C26 tumour-bearing mice. To further explore associated processes and mechanisms we investigated changes in plasma Ca2+ levels, the involvement of parathyroid hormone related protein (PTHrP), and its possible interactions with cyclooxygenase 2 (COX-2). Methods: CD2F1 mice were subcutaneously inoculated with C26 adenocarcinoma cells or sham treated and divided in: (1) controls, (2) tumour-bearing controls, and (3) tumour-bearing receiving experimental diets. After 20 days, body and organ masses and total plasma Ca2+ levels were determined. Furthermore, effects of DHA, EPA and leucine on production of PTHrP were studied in cultured C26 cells. Results: The combination of leucine and fish oil reduced tumour-associated hypercalcemia. Plasma Ca2+ levels negatively correlated with carcass mass and multiple organ masses. DHA was able to reduce PTHrP production by C26 cells in vitro. Results indicate that this effect occurred independently of COX-2 inhibition. Conclusion: Our results suggest that cancer-related hypercalcemia may be ameliorated by a nutritional intervention rich in leucine and fish oil. The effect of fish oil possibly relates to a DHA-induced reduction of PTHrP excretion by the tumour.

Matèries

Aminoàcids, Càncer

Matèries (anglès)

Amino acids, Cancer

Citació

Col·leccions

Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

Citació

PLAS, Rogier l. c., POLAND, Mieke, FABER, Joyce, ARGILÉS HUGUET, Josep ma., DIJK, Miriam van, LAVIANO, Alessandro, MEIJERINK, Jocelijn, WITKAMP, Renger f., HELVOORT, Ardy van, NORREN, Klaske van. A diet rich in fish oil and Leucine Ameliorates Hypercalcemia in tumour-induced cachectic mice. _International Journal of Molecular Sciences_. 2019. Vol. 20, núm. 20, pàgs. 4978. [consulta: 8 de gener de 2026]. ISSN: 1661-6596. [Disponible a: https://hdl.handle.net/2445/158541]

Exportar metadades

JSON - METS

Compartir registre