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2021-06-01

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cc-by (c) Bellver-Sanchis, Aina et al., 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/183088

The Contribution of Epigenetic Inheritance Processes on Age-Related Cognitive Decline and Alzheimer's Disease

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Recurs relacionat

https://doi.org/10.3390/epigenomes5020015

Resum

: During the last years, epigenetic processes have emerged as important factors for many neurodegenerative diseases, such as Alzheimer's disease (AD). These complex diseases seem to have a heritable component; however, genome-wide association studies failed to identify the genetic loci involved in the etiology. So, how can these changes be transmitted from one generation to the next? Answering this question would allow us to understand how the environment can affect human populations for multiple generations and explain the high prevalence of neurodegenerative diseases, such as AD. This review pays particular attention to the relationship among epigenetics, cognition, and neurodegeneration across generations, deepening the understanding of the relevance of heritability in neurodegenerative diseases. We highlight some recent examples of EI induced by experiences, focusing on their contribution of processes in learning and memory to point out new targets for therapeutic interventions. Here, we first describe the prominent role of epigenetic factors in memory processing. Then, we briefly discuss aspects of EI. Additionally, we summarize evidence of how epigenetic marks inherited by experience and/or environmental stimuli contribute to cognitive status offspring since better knowledge of EI can provide clues in the appearance and development of age-related cognitive decline and AD.

Matèries

Malaltia d'Alzheimer, Epigenètica, Estrès oxidatiu

Matèries (anglès)

Alzheimer's disease, Epigenetics, Oxidative stress

Citació

Col·leccions

Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

Citació

BELLVER SANCHIS, Aina, PALLÀS I LLIBERÍA, Mercè and GRIÑÁN FERRÉ, Christian. The Contribution of Epigenetic Inheritance Processes on Age-Related Cognitive Decline and Alzheimer's Disease. Epigenomes. 2021. Vol. 5, num. 2, pags. 1-20. ISSN 2075-4655. [consulted: 15 of August of 2026]. Available at: https://hdl.handle.net/2445/183088

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