Fitxers

940399.pdf (4.8 MB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2026-07-10

Llicència de publicació

cc-by (c) Madurga Díez, Sergio, et al., 2026
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/230658

Immune–Metabolic Profiling Reveals Functional Heterogeneity Within Colorectal Cancer Consensus Molecular Subtypes

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.3390/biology15141128

Resum

The Consensus Molecular Subtype (CMS) classification provides a widely used transcrip- tomic framework for colorectal cancer (CRC) stratification with clear prognostic and thera- peutic relevance. However, it does not fully capture the immune–metabolic heterogeneity underlying tumor–microenvironment interactions within each subtype. Here, we integrate a validated immune–metabolic gene signature as a functional layer to refine CMS classifica- tion and systematically characterize diversity across CMS1-4 tumors. Using transcriptomic data from 2918 CRC samples across three independent cohorts (GSE1, TCGA, and GSE2), we show that CMSs display robust yet distinct immune–metabolic distributions across datasets. CMS4 tumors exhibit glycolytic, stromal-dependent, and immunosuppressive pro- files, whereas CMS2 and CMS3 are enriched in oxidative and metabolically flexible states. Importantly, CMS1 tumors segregate into two major immune–metabolic profiles, revealing marked heterogeneity within this immune-activated subtype. These patterns are preserved in metastatic samples, supporting their stability across disease stages. Overall, integrating immune–metabolic profiling into CMSs reveals previously unrecognized functional het- erogeneity and provides a refined framework to interpret tumor–microenvironment states. This approach facilitates the identification of context-specific metabolic vulnerabilities with potential clinical relevance.

Matèries

Càncer colorectal, Classificació de tumors, Marcadors tumorals

Matèries (anglès)

Colorectal cancer, Tumors classification, Tumor markers

Citació

Col·leccions

Articles publicats en revistes (Ciència dels Materials i Química Física)
Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Institut de Química Teòrica i Computacional (IQTCUB))

Citació

MADURGA DÍEZ, Sergio, et al. Immune–Metabolic Profiling Reveals Functional Heterogeneity Within Colorectal Cancer Consensus Molecular Subtypes. Biology. 2026. Vol. 15, num. 14. ISSN 2079-7737. [consulted: 20 of July of 2026]. Available at: https://hdl.handle.net/2445/230658

Exportar metadades

JSON - METS

Compartir registre