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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/65139
Brain-Derived Neurotrophic Factor as a potential biomarker of cognitive recovery in schizophrenia
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Brain-derived neurotrophic factor (BDNF) has been proposed as a biomarker of schizophrenia and, more specifically, as a biomarker of cognitive recovery. Evidence collected in this review indicates that BDNF is relevant in the pathophysiology of schizophrenia and could play a role as a marker of clinical response. BDNF has been shown to play a positive role as a marker in antipsychotic treatment, and it has been demonstrated that typical antipsychotics decrease BDNF levels while atypical antipsychotics maintain or increase serum BDNF levels. Furthermore, BDNF levels have been associated with severe cognitive impairments in patients with schizophrenia. Consequently, BDNF has been proposed as a candidate target of strategies to aid the cognitive recovery process. There is some evidence suggesting that BDNF could be mediating neurobiological processes underlying cognitive recovery. Thus, serum BDNF levels seem to be involved in some synaptic plasticity and neurotransmission processes. Additionally, serum BDNF levels significantly increased in schizophrenia subjects after neuroplasticity-based cognitive training. If positive replications of those findings are published in the future then serum BDNF levels could be definitely postulated as a peripheral biomarker for the effects of intensive cognitive training or any sort of cognitive recovery in schizophrenia. All in all, the current consideration of BDNF as a biomarker of cognitive recovery in schizophrenia is promising but still premature.
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PENADÉS RUBIO, Rafael, CATALÁN, Rosa, LÓPEZ VILCHEZ, Irene, ARIAS SAMPÉRIZ, Bárbara, GOZÁLEZ-RODRÍGUEZ, Alexandre, GALÁN, Ana m., GASTÓ FERRER, Cristóbal. Brain-Derived Neurotrophic Factor as a potential biomarker of cognitive recovery in schizophrenia. _World Journal of Psychiatry_. 2013. Vol. 3, núm. 4, pàgs. 93-102. [consulta: 23 de gener de 2026]. ISSN: 2220-3206. [Disponible a: https://hdl.handle.net/2445/65139]