Miniatura

Fitxers

699841.pdf (1.22 MB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2012-07-01

Tots els drets reservats

Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/162033

Plasma fibronectin deficiency impedes atherosclerosis progression and fibrous cap formation

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1002/emmm.201200237

Resum

Atherosclerotic lesions are asymmetric focal thickenings of the intima of arteries that consist of lipids, various cell types and extracellular matrix (ECM). These lesions lead to vascular occlusion representing the most common cause of death in the Western world. The main cause of vascular occlusion is rupture of atheromatous lesions followed by thrombus formation. Fibronectin (FN) is one of the earliest ECM proteins deposited at atherosclerosis-prone sites and was suggested to promote atherosclerotic lesion formation. Here, we report that atherosclerosis-prone apolipoprotein E-null mice lacking hepatocyte-derived plasma FN (pFN) fed with a pro-atherogenic diet display dramatically reduced FN depositions at atherosclerosis-prone areas, which results in significantly smaller and fewer atherosclerotic plaques. However, the atherosclerotic lesions from pFN-deficient mice lacked vascular smooth muscle cells and failed to develop a fibrous cap. Thus, our results demonstrate that while FN worsens the course of atherosclerosis by increasing the atherogenic plaque area, it promotes the formation of the protective fibrous cap, which in humans prevents plaques rupture and vascular occlusion.

Matèries

Aterosclerosi, Patologia, Sang

Matèries (anglès)

Atherosclerosis, Pathology, Blood

Citació

Col·leccions

Articles publicats en revistes (Ciències Fisiològiques)

Citació

ROHWEDDER, Ina, MONTAÑEZ, Eloi, BECKMANN, Karsten, BENGTSSON, Eva, DUNÉR, Pontus, NILSSON, Jan, SOEHNLEIN, Oliver, FÄSSLER, Reinhard. Plasma fibronectin deficiency impedes atherosclerosis progression and fibrous cap formation. _EMBO Molecular Medicine_. 2012. Vol. 4, núm. 7, pàgs. 564-576. [consulta: 24 de gener de 2026]. ISSN: 1757-4676. [Disponible a: https://hdl.handle.net/2445/162033]

Exportar metadades

JSON - METS

Compartir registre