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2001-01

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/49299

Constitutive expression of FGF4 disrupts the development of the eye and the anterior CNS during mouse embryogenesi, but does not influence the expressionof shh in these areas.

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The biological consequences of constitutive fibroblast growth factor-4 (fgf4) expression have been analysed during anterior CNS development of mouse chimeric embryos. Severe mutant embryos exhibit exencephaly, absence of eye development and anomalous differentiation of neuropithelium. These embryos also show ectopic limb buds resembling the early phases of limb development. Because our results show that anterior CNS in those chimeric embrios does not express shh ectopically, we suggest that malformations may be due to interference between the ectopic expression of fgf4 in the cephalic area and the receptors for the members of the FGF family that regulate brain and eye development, namely fgf8. If this is correct, the results indirectly suport the crucial role of fgf8 in patterning the anterior CNS.

Matèries

Genètica del desenvolupament, Sistema nerviós central, Ratolins (Animals de laboratori), Factors de creixement

Matèries (anglès)

Developmental genetics, Central nervous system, Mice (Laboratory animals), Growth factors

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Articles publicats en revistes (Genètica, Microbiologia i Estadística)

Citació

BUENO I TORRENS, David, ABUD, Helen, SKINNER, Judith, HEATH, John k.. Constitutive expression of FGF4 disrupts the development of the eye and the anterior CNS during mouse embryogenesi, but does not influence the expressionof shh in these areas.. _Belgian Journal of Zoology_. 2001. Vol. 131, núm. 57-62. [consulta: 20 de gener de 2026]. ISSN: 0777-6276. [Disponible a: https://hdl.handle.net/2445/49299]

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