Chemical rewiring of ubiquitination by degraders and their selectivity routes

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dc.contributor.authorWhelan, Rory
dc.contributor.authorMayor Ruiz, Cristina
dc.date.accessioned2024-04-02T09:28:40Z
dc.date.available2024-08-16T05:10:08Z
dc.date.issued2024-02-16
dc.date.updated2024-03-27T12:07:38Z
dc.description.abstractUbiquitination is an essential process that curtails cellular levels of damaged and redundant proteins. Chemical biologists have harnessed this natural system to induce the degradation of disease-relevant proteins. We reflect here on the potential of ‘degraders’ for targeted selectivity, and discuss the role of computer-aided drug design in shaping future advances.ca
dc.format.extent3 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idimarina6608424
dc.identifier.issn1545-9985
dc.identifier.pmid38366231
dc.identifier.urihttps://hdl.handle.net/2445/209323
dc.language.isoengca
dc.publisherSpringer Natureca
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1038/s41594-024-01215-8
dc.relation.ispartofNature Structural & Molecular Biology, 2024, vol. 31, p. 205-207
dc.relation.urihttps://doi.org/10.1038/s41594-024-01215-8
dc.rights(c) Springer Nature, 2024
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))
dc.subject.classificationDisseny de medicaments
dc.subject.classificationModificació química de les proteïnes
dc.subject.otherDrug design
dc.subject.otherChemical modification of proteins
dc.titleChemical rewiring of ubiquitination by degraders and their selectivity routesca
dc.typeinfo:eu-repo/semantics/articleca
dc.typeinfo:eu-repo/semantics/acceptedVersion

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Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))