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2016-08-24

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cc by (c) Martín et al., 2016
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/105635

Stratification and therapeutic potential of PML in metastatic breast cancer

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http://dx.doi.org/10.1038/ncomms12595

Resum

Patient stratification has been instrumental for the success of targeted therapies in breast cancer. However, the molecular basis of metastatic breast cancer and its therapeutic vulnerabilities remain poorly understood. Here we show that PML is a novel target in aggressive breast cancer. The acquisition of aggressiveness and metastatic features in breast tumours is accompanied by the elevated PML expression and enhanced sensitivity to its inhibition. Interestingly, we find that STAT3 is responsible, at least in part, for the transcriptional upregulation of PML in breast cancer. Moreover, PML targeting hampers breast cancer initiation and metastatic seeding. Mechanistically, this biological activity relies on the regulation of the stem cell gene SOX9 through interaction of PML with its promoter region. Altogether, we identify a novel pathway sustaining breast cancer aggressiveness that can be therapeutically exploited in combination with PML-based stratification.

Matèries

Càncer de mama, Interacció cel·lular

Matèries (anglès)

Breast cancer, Cell interaction

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Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))
<b>Publicacions de projectes de recerca finançats per la UE</b>

Citació

MARTÍN-MARTÍN, Natalia, PIVA, Marco, UROSEVIC, Jelena, ALDAZ, Paula, SUTHERLAND, James david, FERNÁNDEZ-RUIZ, Sonia, ARREAL, Leire, TORRANO, Verónica, CORTAZAR, Ana rosa, PLANET, Evarist, GUIU, Marc, RADOSEVIC ROBIN, Nina, GARCIA, Stephane, MACÍAS, Iratxe, SALVADOR, Fernando, DOMENICI, Giacomo, RUEDA, Oscar m., ZABALA LETONA, Amaia, ARRUABARRENA-ARISTORENA, Amaia, ZÚÑIGA GARCÍA, Patricia, CARO MALDONADO, Alfredo, VALCARCEL-JIMENEZ, Lorea, SÁNCHEZ MOSQUERA, Pilar, VARELA REY, Marta, MARTÍNEZ CHANTAR, Maria luz, ANGUITA, Juan, IBRAHIM, Yasir h., SCALTRITI, Maurizio, LAWRIE, Charles h., ARANSAY, Ana m., IOVANNA, Juan l., BASELGA TORRES, Josep, CALDAS, Carlos, BARRIO, Rosa, SERRA ELIZALDE, Violeta, VIVANCO, Maria d. m., MATHEU, Ander, GOMIS I CABRÉ, Roger, CARRACEDO, Arkaitz. Stratification and therapeutic potential of PML in metastatic breast cancer. _Nature Communications_. 2016. Vol. 7, núm. 12595. [consulta: 25 de gener de 2026]. ISSN: 2041-1723. [Disponible a: https://hdl.handle.net/2445/105635]

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