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2021-02-01

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cc-by-nc (c) Augereau, Adeline et al., 2021
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/193660

Naked mole rat TRF1 safeguards glycolytic capacity and telomere replication under low oxygen.

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https://doi.org/10.1126/sciadv.abe0174

Abstract

The naked mole rat (NMR), a long-lived and cancer-resistant rodent, is highly resistant to hypoxia. Here, using robust cellular models wherein the mouse telomeric protein TRF1 is substituted by NMR TRF1 or its mutant forms, we show that TRF1 supports maximal glycolytic capacity under low oxygen, shows increased nuclear localization and association with telomeres, and protects telomeres from replicative stress. We pinpoint this evolutionary gain of metabolic function to specific amino acid changes in the homodimerization domain of this protein. We further find that NMR TRF1 accelerates telomere shortening. These findings reveal an evolutionary strategy to adapt telomere biology for metabolic control under an extreme environment.

Subject

Rates, Càncer, Oxigen

Subject (English)

Rats, Cancer, Oxygen

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Articles publicats en revistes (Genètica, Microbiologia i Estadística)

Citation

AUGEREAU, Adeline, et al. Naked mole rat TRF1 safeguards glycolytic capacity and telomere replication under low oxygen. Science Advances. 2021. Vol. 7, num. 8. ISSN 2375-2548. [consulted: 9 of June of 2026]. Available at: https://hdl.handle.net/2445/193660

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