Fitxers

RocafortM_Microbiome_2019.pdf (6.02 MB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2019-05-11

Llicència de publicació

cc by (c) Rocafort et al., 2019
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/135189

Evolution of the gut microbiome following acute HIV-1 infection

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

http://dx.doi.org/10.1186/s40168-019-0687-5

Resum

Background: In rhesus macaques, simian immunodeficiency virus infection is followed by expansion of enteric viruses but has a limited impact on the gut bacteriome. To understand the longitudinal effects of HIV-1 infection on the human gut microbiota, we prospectively followed 49 Mozambican subjects diagnosed with recent HIV-1 infection (RHI) and 54 HIV-1-negative controls for 9–18 months and compared them with 98 chronically HIV-1- infected subjects treated with antiretrovirals (n = 27) or not (n = 71). Results: We show that RHI is followed by increased fecal adenovirus shedding, which persists during chronic HIV-1 infection and does not resolve with ART. Recent HIV-1 infection is also followed by transient non-HIV-specific changes in the gut bacterial richness and composition. Despite early resilience to change, an HIV-1-specific signature in the gut bacteriome—featuring depletion of Akkermansia, Anaerovibrio, Bifidobacterium, and Clostridium—previously associated with chronic inflammation, CD8+ T cell anergy, and metabolic disorders, can be eventually identified in chronically HIV-1-infected subjects. Conclusions: Recent HIV-1 infection is associated with increased fecal shedding of eukaryotic viruses, transient loss of bacterial taxonomic richness, and long-term reductions in microbial gene richness. An HIV-1-associated microbiome signature only becomes evident in chronically HIV-1-infected subjects.

Matèries

Microbiota, Infeccions per VIH

Matèries (anglès)

HIV infections

Citació

Col·leccions

Articles publicats en revistes (ISGlobal)

Citació

ROCAFORT, Muntsa, et al. Evolution of the gut microbiome following acute HIV-1 infection. Microbiome. 2019. Vol. 7, num. 73. ISSN 2049-2618. [consulted: 23 of May of 2026]. Available at: https://hdl.handle.net/2445/135189

Exportar metadades

JSON - METS

Compartir registre