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RocafortM_Microbiome_2019.pdf (6.02 MB)

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2019-05-11

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cc by (c) Rocafort et al., 2019
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/135189

Evolution of the gut microbiome following acute HIV-1 infection

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Recurs relacionat

http://dx.doi.org/10.1186/s40168-019-0687-5

Resum

Background: In rhesus macaques, simian immunodeficiency virus infection is followed by expansion of enteric viruses but has a limited impact on the gut bacteriome. To understand the longitudinal effects of HIV-1 infection on the human gut microbiota, we prospectively followed 49 Mozambican subjects diagnosed with recent HIV-1 infection (RHI) and 54 HIV-1-negative controls for 9–18 months and compared them with 98 chronically HIV-1- infected subjects treated with antiretrovirals (n = 27) or not (n = 71). Results: We show that RHI is followed by increased fecal adenovirus shedding, which persists during chronic HIV-1 infection and does not resolve with ART. Recent HIV-1 infection is also followed by transient non-HIV-specific changes in the gut bacterial richness and composition. Despite early resilience to change, an HIV-1-specific signature in the gut bacteriome—featuring depletion of Akkermansia, Anaerovibrio, Bifidobacterium, and Clostridium—previously associated with chronic inflammation, CD8+ T cell anergy, and metabolic disorders, can be eventually identified in chronically HIV-1-infected subjects. Conclusions: Recent HIV-1 infection is associated with increased fecal shedding of eukaryotic viruses, transient loss of bacterial taxonomic richness, and long-term reductions in microbial gene richness. An HIV-1-associated microbiome signature only becomes evident in chronically HIV-1-infected subjects.

Matèries

Microbiota, Infeccions per VIH

Matèries (anglès)

HIV infections

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Articles publicats en revistes (ISGlobal)

Citació

ROCAFORT, Muntsa, et al. Evolution of the gut microbiome following acute HIV-1 infection. Microbiome. 2019. Vol. 7, num. 73. ISSN 2049-2618. [consulted: 20 of August of 2026]. Available at: https://hdl.handle.net/2445/135189

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