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Article

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2021-05-06

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cc-by (c) Guo, Yanru et al., 2021
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/178466

Anaphylaxis: Focus on Transcription Factor Activity.

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https://doi.org/10.3390/ijms22094935

Abstract

Anaphylaxis is a severe allergic reaction, rapid in onset, and can lead to fatal consequences if not promptly treated. The incidence of anaphylaxis has risen at an alarming rate in past decades and continues to rise. Therefore, there is a general interest in understanding the molecular mechanism that leads to an exacerbated response. The main effector cells are mast cells, commonly triggered by stimuli that involve the IgE-dependent or IgE-independent pathway. These signaling pathways converge in the release of proinflammatory mediators, such as histamine, tryptases, prostaglandins, etc., in minutes. The action and cell targets of these proinflammatory mediators are linked to the pathophysiologic consequences observed in this severe allergic reaction. While many molecules are involved in cellular regulation, the expression and regulation of transcription factors involved in the synthesis of proinflammatory mediators and secretory granule homeostasis are of special interest, due to their ability to control gene expression and change phenotype, and they may be key in the severity of the entire reaction. In this review, we will describe our current understanding of the pathophysiology of human anaphylaxis, focusing on the transcription factors' contributions to this systemic hypersensitivity reaction. Host mutation in transcription factor expression, or deregulation of their activity in an anaphylaxis context, will be updated. So far, the risk of anaphylaxis is unpredictable thus, increasing our knowledge of the molecular mechanism that leads and regulates mast cell activity will enable us to improve our understanding of how anaphylaxis can be prevented or treated.

Subject

Anafilaxi, Al·lèrgia

Subject (English)

Anaphylaxis, Allergy

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Articles publicats en revistes (Biomedicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citation

GUO, Yanru, et al. Anaphylaxis: Focus on Transcription Factor Activity. International Journal of Molecular Sciences. 2021. Vol. 22, num. 9. ISSN 1661-6596. [consulted: 20 of August of 2026]. Available at: https://hdl.handle.net/2445/178466

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