Amb motiu del tancament d'estiu, la validació de documents es reprendrà a partir del 28 d'agost de 2026. Disculpeu les molèsties.
Con motivo del cierre de verano, la validación de documentos se reanudará a partir del 28 de agosto de 2026. Disculpad las molestias
Due to the summer closure, document validation will resume starting August 28, 2026. We apologize for any inconvenience.

Fitxers

672412.pdf (410.06 KB)

Tipus de document

Article

Versió

Versió acceptada

Data de publicació

2017-06-17

Llicència de publicació

cc-by-nc-nd (c) Elsevier B.V., 2017
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/112807

Revisiting blood-brain barrier: a chromatographic approach

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1016/j.jpba.2017.06.027

Resum

Drugs designed to reach a pharmacological CNS target must be effectively transported across the blood-brain barrier (BBB), a thin monolayer of endothelial cells tightly attached together between the blood and the brain parenchyma. Because of the lipidic nature of the BBB, several physicochemical partition models have been studied as surrogates for the passive permeation of potential drug candidates across the BBB (octanol-water, alkane-water, PAMPA...). In the last years, biopartition chromatography is gaining importance as a noncellular system for the estimation of biological properties in early stages of drug development. Microemulsions (ME) are suitable mobile phases, because of their ease of formulation, stability and adjustability to a large number of compositions mimicking biological structures. In the present work, several microemulsion liquid chromatographic (MELC) systems have been characterized by means of the Abraham's solvation parameter model, in order to assess their suitability as BBB distribution or permeability surrogates. In terms of similarity between BBB and MELC systems (dispersion forces arising from solute non-bonded electrons, dipolarity/polarizability, hydrogen-bond acidity and basicity, and molecular volume), the passive permeability surface area product (log PS) for neutral (including zwitterions), fully and partially ionized drugs was found to be well correlated with the ME made of 3.3% SDS (w/v; surfactant) 0.8% heptane (w/v; oil phase) and 6.6% 1-butanol (w/v; co-surfactant) in 50 mM aqueous phosphate buffer, pH 7.4.

Matèries

Barrera hematoencefàlica, Cromatografia de líquids

Matèries (anglès)

Blood-brain barrier, Liquid chromatography

Citació

Col·leccions

Articles publicats en revistes (Enginyeria Química i Química Analítica)

Citació

SUBIRATS I VILA, Xavier, et al. Revisiting blood-brain barrier: a chromatographic approach. Journal of Pharmaceutical and Biomedical Analysis. 2017. ISSN 0731-7085. [consulted: 3 of August of 2026]. Available at: https://hdl.handle.net/2445/112807

Exportar metadades

JSON - METS

Compartir registre