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Fossati_S_Environ_Int_2020.pdf (589.02 KB)

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2020-05

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cc by-nc-nd (c) Fossati et al., 2020
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/159638

Prenatal air pollution exposure and growth and cardio-metabolic risk in preschoolers

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http://dx.doi.org/10.1016/j.envint.2020.105619

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-Objectives: We investigated the association between outdoor air pollutants exposure in the first trimester of preg- nancy, and growth and cardio-metabolic risk at four years of age, and evaluated the mediating role of birth weight. Methods: We included mother-child pairs (N = 1,724) from the Spanish INMA birth cohort established in 2003–2008. First trimester of pregnancy nitrogen dioxide (NO2) and fine particles (PM2.5) exposure levels were estimated. Height, weight, waist circumference, blood pressure, and lipids were measured at four years of age. Body mass index (BMI) trajectories from birth to four years were identified. Results: Increased PM2.5 exposure in the first trimester of pregnancy was associated with decreased z-scores of weight (zWeight) and BMI (zBMI) (zWeight change per interquartile range increase in PM2.5 exposure = −0.12; 95% CI: −0.23, −0.01; zBMI change = −0.12; 95% CI: −0.23, −0.01). Higher NO2 and PM2.5 exposure was associated to a reduced risk of being in a trajectory with accelerated BMI gain, compared to children with the average trajectory. Birth weight partially mediated the association between PM2.5 and zWeight and zBMI. PM2.5 and NO2 were not associated with the other cardio-metabolic risk factors. Conclusions: This comprehensive study of many growth and cardio-metabolic risk related outcomes suggests that air pollution exposure during pregnancy may be associated with delays in physical growth in the early years after birth. These findings imply that pregnancy exposure to air pollutants has a lasting effect on growth after birth and require follow-up at later child ages.

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Malalties neonatals, Contaminació

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Neonatal diseases, Pollution

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Articles publicats en revistes (ISGlobal)

Citació

FOSSATI, Serena, VALVI, Damaskini, MARTÍNEZ, David, CIRACH, Marta, ESTARLICH, Marisa, FERNÁNDEZ SOMOANO, Ana, GUXENS, Mònica, IÑIGUEZ, Carmen, IRIZAR, Amaia, LERTXUNDI, Aitana, NIEUWENHUIJSEN, Mark j., TAMAYO URIA, Ibon, VIOQUE, Jesús, TARDÓN, Adonina, SUNYER DEU, Jordi, VRIJHEID, Martine. Prenatal air pollution exposure and growth and cardio-metabolic
                risk in preschoolers. _Environment International_. 2020. Vol. 138, núm. 105619. [consulta: 30 de gener de 2026]. ISSN: 0160-4120. [Disponible a: https://hdl.handle.net/2445/159638]

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