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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/219313
Adipose tissue plasticity in pheochromocytoma patients suggests a role of the splicing machinery in human adipose browning
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Adipose tissue from pheochromocytoma patients acquires brown fat features, making it a valuable model for studying the mechanisms that control thermogenic adipose plasticity in humans. Transcriptomic analyses revealed a massive downregulation of splicing machinery components and splicing regulatory factors in browned adipose tissue from patients, with upregulation of a few genes encoding RNA-binding proteins potentially involved in splicing regulation. These changes were also observed in cell culture models of human brown adipocyte differentiation, confirming a potential involvement of splicing in the cell-autonomous control of adipose browning. The coordinated changes in splicing are associated with a profound modification in the expression levels of splicing-driven transcript isoforms for genes involved in the specialized metabolism of brown adipocytes and those encoding master transcriptional regulators of adipose browning. Splicing control appears to be a relevant component of the coordinated gene expression changes that allow human adipose tissue to acquire a brown phenotype.
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CASTELLÁ GINER, Moisés, BLASCO ROSET, Albert, PEYROU, Marion, GAVALDÀ I NAVARRO, Aleix, VILLARROYA I TERRADE, Joan, QUESADA LÓPEZ, Tania paloma, LORENTE POCH, Leyre, SANCHO, Juan, SZYMCZAK, Florian, PIRON, Anthony, RODRÍGUEZ FERNÁNDEZ, Sonia, CAROBBIO, Stefania, GODAY ARNÓ, Albert, DOMINGO, Pere (domingo pedrol), VIDAL PUIG, Antonio, GIRALT I OMS, Marta, EIZIRIK, Décio l., VILLARROYA I GOMBAU, Francesc, CEREIJO TÉLLEZ, Rubén. Adipose tissue plasticity in pheochromocytoma patients suggests a role of the splicing machinery in human adipose browning. _iScience_. 2023. Vol. 26, núm. 6. [consulta: 12 de abril de 2026]. ISSN: 2589-0042. [Disponible a: https://hdl.handle.net/2445/219313]