Avui, dijous 7 de maig, el Dipòsit Digital no estarà operatiu per tasques d'actualització. Disculpeu les molèsties.
Hoy, jueves 7 de mayo, el Dipòsit Digital no estará operativo debido a tareas de actualización. Disculpen las molestias.
Today, Thursday, May 7th, the Digital Repository will be unavailable due to a system update.

Fitxers

720715.pdf (4.31 MB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2021-08-03

Llicència de publicació

cc-by (c) Blanco-Cabra, Núria et al., 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/198404

A new BiofilmChip device as a personalized solution for testing biofilm antibiotic resistance

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1038/s41522-021-00236-1

Resum

Currently, three major circumstances threaten the management of bacterial infections: increasing antimicrobial resistance, expansion of chronic biofilm-associated infections, and lack of an appropriate approach to treat them. To date, the development of accelerated drug susceptibility testing of biofilms and of new antibiofouling systems has not been achieved despite the availability of different methodologies. There is a need for easy-to-use methods of testing the antibiotic susceptibility of bacteria that form biofilms and for screening new possible antibiofilm strategies. Herein, we present a microfluidic platform with an integrated interdigitated sensor (BiofilmChip). This new device allows an irreversible and homogeneous attachment of bacterial cells of clinical origin, even directly from clinical specimens, and the biofilms grown can be monitored by confocal microscopy or electrical impedance spectroscopy. The device proved to be suitable to study polymicrobial communities, as well as to measure the effect of antimicrobials on biofilms without introducing disturbances due to manipulation, thus better mimicking real-life clinical situations. Our results demonstrate that BiofilmChip is a straightforward tool for antimicrobial biofilm susceptibility testing that could be easily implemented in routine clinical laboratories.

Matèries

Malalties bacterianes, Biofilms, Sistema monoxip

Matèries (anglès)

Bacterial diseases, Biofilms, Systems on a chip

Citació

Col·leccions

Articles publicats en revistes (Genètica, Microbiologia i Estadística)

Citació

BLANCO-CABRA, Núria, et al. A new BiofilmChip device as a personalized solution for testing biofilm antibiotic resistance. npj Biofilms and Microbiomes. 2021. Vol. 7, núm. 62, pàgs. 1-9. ISSN 2055-5008. [consulta: 8 de maig de 2026]. Disponible a: https://hdl.handle.net/2445/198404

Exportar metadades

JSON - METS

Compartir registre