Towards a glutathione-cleavable azobenzene linker for antibody–drug conjugates

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dc.contributor.authorKapun, Mia
dc.contributor.authorPatel, Roshan
dc.contributor.authorPark, Mahri
dc.contributor.authorPérez Areales, Francisco Javier
dc.contributor.authorKostadinova, Kristina A.
dc.contributor.authorWharton, Thomas
dc.contributor.authorCarroll, Jason S.
dc.contributor.authorSpring, David R.
dc.date.accessioned2025-12-16T08:33:44Z
dc.date.available2025-12-16T08:33:44Z
dc.date.issued2025-10-28
dc.date.updated2025-12-16T08:33:44Z
dc.description.abstractHerein we describe the development of a novel azobenzene-containing glutathione-cleavable linker for use in antibody–drug conjugates (ADCs). This linker demonstrated efficient payload release under elevated glutathione levels while maintaining stability in human plasma. An anti-HER2 ADC incorporating this linker exhibited potent <em>in vitro</em> cytotoxicity and selective activity towards HER2-positive cell lines.
dc.format.extent4 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec762928
dc.identifier.issn1359-7345
dc.identifier.urihttps://hdl.handle.net/2445/224959
dc.language.isoeng
dc.publisherRoyal Society of Chemistry
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1039/D5CC05824D
dc.relation.ispartofChemical Communications, 2025, vol. 61, p. 18902-18905
dc.relation.urihttps://doi.org/10.1039/D5CC05824D
dc.rightscc-by (c) Mia Kapun et al., 2025
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.classificationFotofarmacologia
dc.subject.classificationSíntesi de pèptids
dc.subject.classificationEstrès oxidatiu
dc.subject.classificationGlutatió
dc.subject.otherPhotopharmacology
dc.subject.otherPeptide synthesis
dc.subject.otherOxidative stress
dc.subject.otherGlutathione
dc.titleTowards a glutathione-cleavable azobenzene linker for antibody–drug conjugates
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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